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Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients.
MedLine Citation:
PMID:  23298162     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Ficolin-2 is a kind of human serum complement lectin with a structure similar to mannan-binding lectin (MBL), and it has been implicated in innate immunity. Recent studies have shown that complement pathway activation may contribute to hepatitis. However, the relationship between ficolin-2 and viral hepatitis remains largely elusive. The aim of this study was to determine the dynamics of ficolin-2 in chronic hepatitis C patients. METHODS: 49 patients that had not yet received therapy (24 patients with abnormal ALT levels (>40 U/L) and 25 patients with normal alanine aminotransferase (ALT) levels (≤40 U/L)), 28 hepatitis C patients received therapy for two weeks and 16 patients received therapy for a full month or longer were included in the study. A sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the ficolin-2 concentrations in all serum samples of patients and 42 healthy donors. RESULTS: We found the concentrations of ficolin-2 were significantly higher in chronic hepatitis C patients with abnormal ALT values than in chronic hepatitis C patients with normal ALT values and healthy controls. Ficolin-2 concentrations in chronic hepatitis C patients with abnormal ALT values was positively correlated with ALT levels (* p<0.05). After therapy, the concentrations of ficolin-2 decreased accompany with ALT and HCV RNA levels. Then we found ficolin-2 concentrations in rapid viral response (RVR) group decreased significantly (* p<0.05), while in non-RVR group ficolin-2 decreased slightly (p>0.05). CONCLUSION: Our findings suggest that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response.
Authors:
Yilan Hu; Fengling Luo; Junliang Fu; Tielong Chen; Shimin Wu; Yi-Dan Zhou; Xiao-Lian Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  -     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Scandinavian Journal of Immunology © 2013 Blackwell Publishing Ltd.
Affiliation:
State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, Department of Immunology, Wuhan, 430071, P.R. China; Department of Immunology, Wuhan University of Science and Technology School of Medicine, Wuhan, 430081, P.R. China.
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