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Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients.
MedLine Citation:
PMID:  23298162     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIM: Ficolin-2 is a kind of human serum complement lectin with a structure similar to mannan-binding lectin (MBL), and it has been implicated in innate immunity. Recent studies have shown that complement pathway activation may contribute to hepatitis. However, the relationship between ficolin-2 and viral hepatitis remains largely elusive. The aim of this study was to determine the dynamics of ficolin-2 in chronic hepatitis C patients. METHODS: 49 patients that had not yet received therapy (24 patients with abnormal ALT levels (>40 U/L) and 25 patients with normal alanine aminotransferase (ALT) levels (≤40 U/L)), 28 hepatitis C patients received therapy for two weeks and 16 patients received therapy for a full month or longer were included in the study. A sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the ficolin-2 concentrations in all serum samples of patients and 42 healthy donors. RESULTS: We found the concentrations of ficolin-2 were significantly higher in chronic hepatitis C patients with abnormal ALT values than in chronic hepatitis C patients with normal ALT values and healthy controls. Ficolin-2 concentrations in chronic hepatitis C patients with abnormal ALT values was positively correlated with ALT levels (* p<0.05). After therapy, the concentrations of ficolin-2 decreased accompany with ALT and HCV RNA levels. Then we found ficolin-2 concentrations in rapid viral response (RVR) group decreased significantly (* p<0.05), while in non-RVR group ficolin-2 decreased slightly (p>0.05). CONCLUSION: Our findings suggest that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response.
Yilan Hu; Fengling Luo; Junliang Fu; Tielong Chen; Shimin Wu; Yi-Dan Zhou; Xiao-Lian Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  -     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Scandinavian Journal of Immunology © 2013 Blackwell Publishing Ltd.
State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, Department of Immunology, Wuhan, 430071, P.R. China; Department of Immunology, Wuhan University of Science and Technology School of Medicine, Wuhan, 430081, P.R. China.
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