| Early in vivo MR spectroscopy findings in organophosphate-induced brain damage-potential biomarkers for short-term survival. | |
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MedLine Citation:
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PMID: 22247007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Organophosphates are highly toxic substances, which cause severe brain damage. The hallmark of the brain injury is major convulsions. The goal of this study was to assess the spatial and temporal MR changes in the brain of paraoxon intoxicated rats. T2-weighted MRI and (1) H-MR-spectroscopy were conducted before intoxication, 3 h, 24 h, and 8 days postintoxication. T2 prolongation mainly in the thalami and cortex was evident as early as 3 h after intoxication (4-6% increase in T2 values, P < 0.05). On spectroscopy, N-acetyl aspartate (NAA)/creatine and NAA/choline levels significantly decreased 3 h postintoxication (>20% decrease, P < 0.005), and 3 h lactate peak was evident in all intoxicated animals. On the 8th day, although very little T2 changes were evident, NAA/creatine and choline/creatine were significantly decreased (>15%, P < 0.05). Animals who succumbed had extensive cortical edema, significant higher lactate levels and a significant decrease in NAA/creatine and NAA/choline levels compared to animals which survived the experiment. Organophosphates-induced brain damage is obvious on MR data already 3 h postintoxication. In vivo spectroscopic changes are more sensitive for assessing long-term injury than T2-weighted MR imaging. Early spectroscopic findings might be used as biomarkers for the severity of the intoxication and might predict early survival. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Shai Shrot; Debbie Anaby; Amir Krivoy; Igor Makarovsky; Yossi Rosman; Eugenia Bloch-Shilderman; Shlomi Lazar; Amnon Bar-Shir; Yoram Cohen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Chemical, Biological and Nuclear Medicine Branch, Medical Corps, IDF, Tel-Hashomer Military Base, Israel; Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel-Hashomer, Israel. shaishrot@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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