Document Detail

Early improvement of left ventricular function after implantation of a transcutaneous aortic valve: a tissue Doppler ultrasound study.
MedLine Citation:
PMID:  19427608     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The long-term effects of surgical treatment for aortic narrowing in left ventricular (LV) remodelling have been well described. The immediate benefit after release of obstruction is unknown.
METHOD AND RESULTS: Nineteen patients with significant and symptomatic aortic stenosis underwent transcutaneous implantation of an aortic valve. A conventional and tissue Doppler echocardiography was performed 48 hours before and 24 hours after the procedure. Apart from the dimensions, LV function and aortic haemodynamics, we measured systolic and diastolic myocardial velocities and systolic strain. The procedure resulted in a decrease to the mean transaortic gradient (from 43+/-13 to 10+/- 3 mmHg, p=0.001), an increase of the aortic surface area (from 0.6+/-0.1 to 1.7+/-0.1cm(2), p=0.001) and a reduction in the systolic LV volume (62+/-27 to 48+/-22, p=0.04). We observed an improvement in the systolic radial and longitudinal strain of the posterior wall (p<0.05), septal wall (p<0.05) and lateral wall (p<0.05). Improvement in systolic velocities on these walls and the inferior wall (p<0.01) was also recorded. The regional diastolic velocity was significantly better on the posterior (p<0.05) and septal (p<0.05) walls.
CONCLUSION: The immediate drop in the transaortic gradient resulted in an improvement in myocardial velocities and strain, a sign of improvement in the regional systolic and diastolic regional function.
Fabrice Bauer; Sandra Bénigno; Mathieu Lemercier; Sidney Tapiéro; Hélène Eltchaninoff; Christophe Tron; Brahim Baala; Damien Brunet; Alain Cribier
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Publication Detail:
Type:  Journal Article     Date:  2009-04-02
Journal Detail:
Title:  Archives of cardiovascular diseases     Volume:  102     ISSN:  1875-2136     ISO Abbreviation:  Arch Cardiovasc Dis     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-28     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  101465655     Medline TA:  Arch Cardiovasc Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Cardiology Department, Charles-Nicolle Hospital, Rouen University Hospital, 1, 76031 Rouen cedex, Rouen, France.
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MeSH Terms
Aged, 80 and over
Aortic Valve Stenosis / physiopathology,  surgery*,  ultrasonography
Echocardiography, Doppler, Color*
Heart Valve Prosthesis Implantation*
Middle Aged
Myocardial Contraction
Predictive Value of Tests
Recovery of Function
Severity of Illness Index
Time Factors
Treatment Outcome
Ventricular Function, Left*
Ventricular Remodeling*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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