| Early impairment of myocardial function in young patients with beta-thalassemia major. | |
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MedLine Citation:
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PMID: 18284626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: One of the chief causes of death in patients with beta-thalassemia major (TM) remains heart failure due to iron overload. We investigated possible differences in myocardial function between a population of young asymptomatic patients with TM and healthy controls all of whom underwent an echocardiographic study, including tissue Doppler (TDI) and strain imaging (SI) analysis and cardiac magnetic resonance imaging (MRI). METHODS: 30 young asymptomatic patients with TM (16 taking deferoxamine and 14 taking deferiprone) and 30 healthy subjects underwent a cardiac MRI with T2* technique and an echocardiographic evaluation including systolic myocardial velocities (Sm), early (Em) and late (Am) diastolic velocities and systolic strain (S) at the level of basal segments of the lateral left ventricle (LV), interventricular septum (Septal) and lateral right ventricle (RV) wall. The differences in T2* values and echocardiographic parameters were also compared in patients with TM subgrouped according to iron chelation therapy. RESULTS: The following TDI and SI measures were lower in patients than in controls: LV-Sm (P < 0.05), S-LV (P < 0.001), Septal-Sm (P < 0.05), Septal-Em (P < 0.001), S-Septal (P < 0.001), RV-Sm (P < 0.001), RV-Em (P < 0.001), RV-Em/Am (P < 0.05) and S-RV (P < 0.05). Myocardial function was better in the patients receiving deferiprone than those receiving deferoxamine. T2* values were higher in controls than in patients with TM and in those treated with deferiprone than those treated with deferoxamine. MRI data well correlated with SI parameters. CONCLUSIONS: Study underlines that, even in a population of young, asymptomatic and well-chelated patients with TM, there is an impairment of myocardial function and that this condition could be easily detected by more advanced ultrasound techniques such as TDI and SI. The better indices of myocardial function in patients treated with deferiprone clearly needs confirmation from larger prospective studies. |
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Authors:
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Damiano Magrì; Susanna Sciomer; Francesco Fedele; Gianfranco Gualdi; Emanuele Casciani; Pellegrina Pugliese; Anna Losardo; Giancarlo Ferrazza; Eleonora Pasquazzi; Erika Schifano; Eleonora Mussino; Raffaele Quaglione; Gianfranco Piccirillo |
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Publication Detail:
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Type: Journal Article Date: 2008-02-12 |
Journal Detail:
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Title: European journal of haematology Volume: 80 ISSN: 1600-0609 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: Denmark |
Other Details:
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Languages: eng Pagination: 515-22 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Cardiovascolari, Respiratorie e Morfologiche, Università degli Studi di Roma La Sapienza, Rome, Italy. damiano.magri@libero.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Echocardiography Female Heart / physiopathology* Humans Magnetic Resonance Imaging Male Retrospective Studies beta-Thalassemia / physiopathology* |
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