| Early immune events in the induction of allergic contact dermatitis. | |
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MedLine Citation:
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PMID: 22240625 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The skin is a barrier site that is exposed to a wide variety of potential pathogens. As in other organs, pathogens that invade the skin are recognized by pattern-recognition receptors (PRRs). Recently, it has been recognized that PRRs are also engaged by chemical contact allergens and, in susceptible individuals, this elicits an inappropriate immune response that results in allergic contact dermatitis. In this Review, we focus on how contact allergens promote inflammation by activating the innate immune system. We also examine how innate immune cells in the skin, including mast cells and dendritic cells, cooperate with each other and with T cells and keratinocytes to initiate and drive early responses to contact allergens. |
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Authors:
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Daniel H Kaplan; Botond Z Igyártó; Anthony A Gaspari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: - ISSN: 1474-1741 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Center for Immunology, University of Minnesota, MBB 3-146, 2101 6th St. SE, Minneapolis, Minnesota 55414, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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