Document Detail

Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants.
MedLine Citation:
PMID:  17443195     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Necrotizing enterocolitis (NEC) is a frequent cause of mortality and morbidity in very low birth weight (VLBW) infants. Human milk (HM) feeding has been associated with lower risk of NEC. However, mothers of VLBW infants often experience insufficient milk production, resulting in mixed feedings of HM and formula. Moreover, medical complications often limit the volume of feeding they can be given. OBJECTIVE: To determine if high proportions of (50% or greater) HM enteral feeding within the first 14 days of life are protective against NEC. METHOD: This was a prospective cohort study of VLBW infants who were grouped according to the HM proportion of enteral feeding in the first 14 days: <50% (low human milk, LHM, n=46) and > or =50% (high human milk, HHM, n=156). The outcome of interest was development of NEC (Bell stage 2 or 3). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) and to assess potential confounding due to perinatal risk factors. RESULT: Two hundred and two infants were studied. Confirmed NEC occurred in 5/46 (10.6%) of the LHM group, as compared with 5/156 (3.2%) of the HHM. Gestational age was the only perinatal factor associated with risk of NEC. After adjustment for gestational age, HHM was associated with a lower risk of NEC ((OR=0.17, 95% CI: 0.04 to 0.68), P=0.01). CONCLUSION: Enteral feeding containing at least 50% HM in the first 14 days of life was associated with a sixfold decrease in the odds of NEC.
P M Sisk; C A Lovelady; R G Dillard; K J Gruber; T M O'Shea
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-19
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  428-33     Citation Subset:  IM    
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Cohort Studies
Enterocolitis, Necrotizing / etiology,  prevention & control*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Very Low Birth Weight*
Milk, Human*
Odds Ratio
Prospective Studies
Erratum In:
J Perinatol. 2007 Dec;27(12):808

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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