Document Detail


Early high CMV seroprevalence in pregnant women from a population with a high rate of congenital infection.
MedLine Citation:
PMID:  23200458     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY Congenital cytomegalovirus (CMV) infection rates increase with maternal seroprevalence due to transmission from maternal non-primary infection. CMV seroprevalence estimates of pregnant women are needed for planning strategies against congenital CMV transmission. We aimed to determine the age-specific prevalence of serum antibodies for CMV in a representative age-stratified sample of unselected pregnant women from a Brazilian population. A total of 985 pregnant women, aged 12-46 years (median 24 years), were enrolled. Overall CMV seroprevalence was 97% (95% confidence interval 95·8-98·0), with age-specific (years) prevalence as follows: 12-19 (96·3%), 20-24 (97·7%), 25-29 (97·1%), and 30-46 (96·7%). CMV seroprevalence is almost universal (97%) and is found at similar levels in pregnant women of ages ranging from 12 to 46 years. Because high CMV seroprevalence is found even in women of a younger age in this population, this finding suggests that the majority of primary CMV infections occur early, in infancy or childhood. As a consequence, vaccines currently under development to prevent primary infection may not be a solution for the prevention of congenital CMV infection in this population.
Authors:
A Y Yamamoto; R A C Castellucci; D C Aragon; M M Mussi-Pinhata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Epidemiology and infection     Volume:  -     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Affiliation:
Department of Paediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
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