| Early high C-reactive protein in infants with open abdominal wall defects does not predict sepsis or adverse outcome. | |
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MedLine Citation:
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PMID: 19735496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study CRP values and relate it to outcome in infants with antenatal diagnosis of gastroschisis, exomphalos and other surgical conditions. METHODS: Over five years, infants admitted to our neonatal unit with gastroschisis, exomphalos and other surgical diagnoses were identified. Serum CRP measurements in first 5 days were studied. Group one included 33 gastroschisis patients, group two, 18 exomphalos patients, and group three, 38 patients with other surgical diagnoses. Outcome measures included TPN days, time to full feeds and duration of hospitalization. RESULTs: Infants with gastroschisis were more premature (36.9 vs 38.1 weeks) with lower birth weights (2515 vs 3078 g), than infants with exomphalos. CRP values on admission in gastroschisis group were significantly higher than exomphalos and other diagnoses groups (33.7 +/- 6.4 vs 8.8 +/- 6.0 vs 5.7 +/- 2.0, respectively, p < 0.05). All blood cultures were sterile. There was no relationship between high CRP and death or adverse outcome (TPN days, time to full feeds or duration of hospitalization) in the gastroschisis group. CONCLUSION: Infants with gastroschisis exhibit high early CRP, which may not indicate sepsis or adverse outcome. This increase can complicate the assessment of these infants. Clinicians should be aware of this finding as it could inform management decisions in this group. |
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Authors:
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G Ramadan; D Rex; B Okoye; N L Kennea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 126-30 Citation Subset: IM |
Affiliation:
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Regional Neonatal Intensive Care Unit, St George's Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Birth Weight C-Reactive Protein / analysis* Gastroschisis / blood*, complications, surgery Gestational Age Hernia, Umbilical / blood*, complications, surgery Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases Length of Stay / statistics & numerical data Predictive Value of Tests Risk Factors Sepsis / etiology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
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