Document Detail


Early gray-matter and white-matter concentration in infancy predict later language skills: a whole brain voxel-based morphometry study.
MedLine Citation:
PMID:  23274797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Magnetic resonance imaging (MRI) brain scans were obtained from 19 infants at 7 months. Expressive and receptive language performance was assessed at 12 months. Voxel-based morphometry (VBM) identified brain regions where gray-matter and white-matter concentrations at 7 months correlated significantly with children's language scores at 12 months. Early gray-matter concentration in the right cerebellum, early white-matter concentration in the right cerebellum, and early white-matter concentration in the left posterior limb of the internal capsule (PLIC)/cerebral peduncle were positively and strongly associated with infants' receptive language ability at 12 months. Early gray-matter concentration in the right hippocampus was positively and strongly correlated with infants' expressive language ability at 12 months. Our results suggest that the cerebellum, PLIC/cerebral peduncle, and the hippocampus may be associated with early language development. Potential links between these structural predictors and infants' linguistic functions are discussed.
Authors:
Dilara Deniz Can; Todd Richards; Patricia K Kuhl
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-27
Journal Detail:
Title:  Brain and language     Volume:  124     ISSN:  1090-2155     ISO Abbreviation:  Brain Lang     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-04     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7506220     Medline TA:  Brain Lang     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Brain / growth & development*,  physiology
Brain Mapping / methods*
Cerebellum / growth & development,  physiology
Cerebral Cortex / growth & development,  physiology
Child Language*
Cognition / physiology
Female
Hippocampus / growth & development,  physiology
Humans
Infant
Internal Capsule / growth & development,  physiology
Language Development*
Magnetic Resonance Imaging / methods*
Male
Predictive Value of Tests
Grant Support
ID/Acronym/Agency:
HD37954/HD/NICHD NIH HHS; P30 DC004661/DC/NIDCD NIH HHS; P30 DC04661/DC/NIDCD NIH HHS; R01 HD037954/HD/NICHD NIH HHS
Comments/Corrections

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