| Early gray-matter and white-matter concentration in infancy predict later language skills: A whole brain voxel-based morphometry study. | |
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MedLine Citation:
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PMID: 23274797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Magnetic Resonance Imaging (MRI) brain scans were obtained from 19 infants at 7months. Expressive and receptive language performance was assessed at 12months. Voxel-based morphometry (VBM) identified brain regions where gray-matter and white-matter concentrations at 7months correlated significantly with children's language scores at 12months. Early gray-matter concentration in the right cerebellum, early white-matter concentration in the right cerebellum, and early white-matter concentration in the left posterior limb of the internal capsule (PLIC)/cerebral peduncle were positively and strongly associated with infants' receptive language ability at 12months. Early gray-matter concentration in the right hippocampus was positively and strongly correlated with infants' expressive language ability at 12months. Our results suggest that the cerebellum, PLIC/cerebral peduncle, and the hippocampus may be associated with early language development. Potential links between these structural predictors and infants' linguistic functions are discussed. |
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Authors:
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Dilara Deniz Can; Todd Richards; Patricia K Kuhl |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-26 |
Journal Detail:
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Title: Brain and language Volume: 124 ISSN: 1090-2155 ISO Abbreviation: Brain Lang Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506220 Medline TA: Brain Lang Country: - |
Other Details:
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Languages: ENG Pagination: 34-44 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute for Learning & Brain Sciences, University of Washington, United States. Electronic address: dilara@u.washington.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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