| Early glottic carcinoma treated by radiotherapy: Defining a population for surgical salvage. | |
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MedLine Citation:
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PMID: 23007323 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: Not all patients with early Glottis squamous cell carcinoma will be cured by radiotherapy. This is an audit of a single center's experience with those patients who fail by this approach. STUDY DESIGN: This retrospective study was approved by the IRB (Institutional Review Board); eligibility criterion was patients treated between 1967 and December 2006, T(IS) , T(1) , T(2) N(0) SCC glottic carcinoma, with analysis occurring in 2009, and with a minimum follow-up of 2 years. METHODS: The eligibility criteria for this ethics-approved study was that all patients started a course of radiotherapy for early glottic laryngeal SCC. Data included in the Larynx Cancer database includes information from the Radiation Oncology Department notes, referral letters, and follow-up information. This is categorized into patient, disease, and treatment factors. RESULTS: Of 522 patients who commenced radiotherapy, local failure occurred in 105 patients; a salvage procedure was performed in 89, with surgery only in 83. For these 89 patients, the ultimate local control was 67%, with a larynx preservation procedure in 34%. Nodal failure occurred in 20 of the 522 patients (4%). There was a much higher failure rate in patients unfit for surgery (10/26-38%). Laryngectomy was the main salvage procedure in 55 patients. CONCLUSIONS: Early recognition of local failure following radiotherapy for early glottic carcinoma may avoid laryngectomy as a salvage procedure. |
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Authors:
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Robert I Smee; Janet R Williams; Kathryn Broadley; G P Bridger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-24 |
Journal Detail:
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Title: The Laryngoscope Volume: - ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc. |
Affiliation:
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Department of Radiation Oncology, The Prince of Wales Cancer Centre, New South Wales, Australia; Faculty of Medicine, Prince of Wales Clinical School, University of New South Wales, New South Wales, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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