| Early gastrointestinal regulatory peptide response to intestinal resection in the rat is stimulated by enteral glutamine supplementation. | |
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MedLine Citation:
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PMID: 10436367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intestinal resection stimulates the synthesis and release of gastrointestinal peptides that regulate the growth and adaptation of the mucosa. Luminal nutrients are necessary for optimal proliferation and glutamine is the preferential nutrient to the small bowel. The interplay between glutamine and regulatory peptides could be important in treating short bowel syndrome. METHODS: 63 Sprague-Dawley rats were divided into 3 groups: resection; transection, or controls. After intestinal resection animals were orally fed either a diet without glutamine or a glutamine-supplemented diet for 2 days. Transected animals and controls without prior surgery were fed the same two diets. Epidermal growth factor (EGF), transforming growth factor-alpha, insulin-like growth factors I and II (IGF-I and IGF-II), peptide YY (PYY), and enteroglucagon were analyzed in mucosa from the proximal jejunum, distal ileum as well as in portal plasma when the animals were euthanized 72 h after surgery. RESULTS: Intestinal resection resulted in an early increase in portal plasma concentrations of PYY, EGF, enteroglucagon, and mucosal IGF-II and EGF content that were significant in glutamine-treated animals. Glutamine significantly increased PYY in portal blood after resection (p < 0.05). CONCLUSION: Glutamine could be of importance for the functional adaptation of residual small bowel mucosa by increasing PYY release. |
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Authors:
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M Wirén; T E Adrian; U Arnelo; J Permert; P Staab; J Larsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive surgery Volume: 16 ISSN: 0253-4886 ISO Abbreviation: Dig Surg Publication Date: 1999 |
Date Detail:
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Created Date: 2000-05-19 Completed Date: 2000-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501808 Medline TA: Dig Surg Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 197-203 Citation Subset: IM |
Affiliation:
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Department of Surgery, Faculty of Health Sciences, University of Linköping, Sweden. Mikael.Wiren@lio.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epidermal Growth Factor / metabolism Gastrointestinal Hormones / metabolism* Glucagon-Like Peptides / metabolism Glutamine / pharmacology* Insulin-Like Growth Factor I / metabolism Insulin-Like Growth Factor II / metabolism Intestinal Mucosa / metabolism Intestines / surgery* Male Peptide YY / metabolism Rats Rats, Sprague-Dawley Transforming Growth Factor alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Transforming Growth Factor alpha; 106388-42-5/Peptide YY; 56-85-9/Glutamine; 62229-50-9/Epidermal Growth Factor; 62340-29-8/Glucagon-Like Peptides; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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