Document Detail

Early functional closure of the ductus arteriosus associated with decreased severity of respiratory distress syndrome in preterm infants.
MedLine Citation:
PMID:  577658     Owner:  NLM     Status:  MEDLINE    
It has been shown that a patent ductus arteriosus may complicate the course of the respiratory distress syndrome (RDS) in preterm infants. In this study, an attempt is made to answer the question: Is there any relationship between RDS and patency of the ductus arteriosus in preterm infants, that is, do preterm infants without the RDS have early functional closure of the ductus arteriosus? Clinical observations were made on 144 preterm infants 25 to 34 weeks' gestation. Infants were included in the study if the status of the ductus arteriosus (open or closed) could be established either by clinical examination or retrograde aortography. The ductus arteriosus was closed in 59 infants within 48 hours of birth and open in 85. None of the infants with a closed ductus had severe RDS and only three had mild RDS. In contrast, 50% (43 of 85) of infants with open ductus had severe RDS. These findings suggest that early functional closure of the ductus can occur even in very immature infants, and this early closure appears to be associated with a decreased incidence of RDS.
D W Thibeault; G C Emmanouilides; M E Dodge; R S Lachman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  131     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  741-5     Citation Subset:  AIM; IM    
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MeSH Terms
Ductus Arteriosus / physiology*
Ductus Arteriosus, Patent / physiopathology*,  radiography
Gestational Age
Infant, Newborn
Pulmonary Surfactants / physiology
Respiratory Distress Syndrome, Newborn / physiopathology*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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