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Early first-trimester maternal serum placental growth factor (PlGF) in trisomy 21 pregnancies.
MedLine Citation:
PMID:  21105022     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To measure maternal serum placental growth factor (PlGF) levels in trisomy 21 cases and controls in samples drawn before 11 weeks gestation. METHODS: Early first trimester maternal serum samples for 37 trisomy 21 cases and 244 unaffected controls were retrieved from frozen storage and PlGF was retrospectively measured using a DELFIA Xpress immunoassay platform. PlGF levels were converted to multiples of the median and trisomy 21 and unaffected groups were compared. RESULTS: Raw PlGF and MoM levels were significantly higher in the maternal serum of trisomy 21 cases compared to controls over the three week gestational window (unaffected 1.0 MoM compared to trisomy 21 1.3 MoM (p < 0.0001)). However at eight completed weeks of gestation the increase was most significant and at ten completed weeks there was no significant difference between trisomy 21 and unaffected PlGF levels. CONCLUSIONS: Early PlGF levels in maternal serum in trisomy 21 cases may be increased relative to unaffected controls, however PlGF levels in trisomy 21 and unaffected pregnancies in the first two trimesters of pregnancy appears complex and requires further study. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Cowans Nj; Stamatopoulou A; Tørring N; Spencer K
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-23
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, Essex, United Kingdom.
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