| Early fetal obstructive uropathy produces Potter's syndrome in the lamb. | |
| | |
MedLine Citation:
|
PMID: 11083420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: If creating an obstructive uropathy early in glomerulogenesis produces MCDK (Multicystic Dysplastic Kidney), then a very early obstruction may produce Potter's Syndrome (PS) with oligohydramnios. METHODS: Fetal lambs at 50 days' gestation underwent urethral and urachal ligation using fine SILASTIC (Dow Corning, Midland, MI) tubing and were delivered by cesarean section at 145 days' gestation. At the time of death, kidney weight, length, and lung volumes were measured. These samples were examined histologically. Urinary sodium, chloride, potassium, and osmolarity also were measured. These were compared with normal-term fetuses. RESULTS: One ewe miscarried. Two of 3 of 50-day obstructive uropathy lambs survived. The 2 survivors had dysplastic kidneys. One with large gastroschisis did not have PS but the other had renal, pulmonary, and chest wall hypoplasia. Both male lambs had undescended testes with a large bladder. Kidney weights were 2 g in the PS lamb and 16 g in controls. Lung volume was 84 mL in the PS lamb and 340 mL in controls. The lamb's face was compressed and the fetus was hydropic. Urine sodium, potassium, and osmolarity levels were higher than that of controls. CONCLUSIONS: This is the first successful model ligating the penile urethra and urachus in a 50-day lamb. The authors' previous 60-day model did not have PS, but an earlier obstructive uropathy caused MCDK with PS. |
| | |
Authors:
|
H Kitagawa; K C Pringle; J Zucollo; J Koike; K Nakada; H Moriya; Y Seki |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of pediatric surgery Volume: 35 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-12-07 Completed Date: 2002-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 1549-53 Citation Subset: IM |
Affiliation:
|
Department of Pathology, St Marianna University School of Medicine, Kawasaki, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Multiple
/
etiology* Animals Disease Models, Animal Face / abnormalities* Female Fetal Diseases / embryology* Gestational Age Immunohistochemistry Kidney / pathology* Lung / pathology* Male Nose / abnormalities* Oligohydramnios / diagnosis, etiology* Organ Size Pregnancy Pregnancy, Animal Reference Values Risk Assessment Sheep Syndrome Ureteral Obstruction / complications*, diagnosis, embryology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical aspects of dialysis in newborns and infants weighing less than ten kilograms.
Next Document: Xanthogranulomatous pyelonephritis in childhood: a rare but important clinical entity.