| Early fetal growth, PAPP-A and free β-hCG in relation to risk of delivering a small-for-gestational age infant. | |
| | |
MedLine Citation:
|
PMID: 20737455 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVES: To examine early fetal growth, pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG) in relation to the risk of delivering a small-for-gestational age (SGA) infant. METHODS: Included in the study were 9450 singleton pregnant women who attended the prenatal screening program at Aarhus University Hospital, Denmark, between January 2005 and December 2007. Maternal serum levels of PAPP-A and free β-hCG were measured between gestational weeks 8 and 13. Two ultrasound examinations were performed, the first at 11-13 weeks and the second at 18-22 weeks, from which gestational age was estimated based on crown-rump length and biparietal diameter, respectively. Early fetal growth was expressed as an index: the ratio between the estimated number of days from the first to the second scan and the actual calendar time elapsed in days. SGA was defined as birth weight < 5(th) centile for gestational age, and the risk of SGA was evaluated according to different cut-offs of the early fetal growth index and the serum markers. RESULTS: PAPP-A < 0.4 MoM combined with an early fetal growth index < 10(th) centile resulted in an increased risk of SGA (odds ratio (OR), 5.8; 95% CI, 2.7-12.7). Low PAPP-A, low free β-hCG and slow early fetal growth were statistically, independently associated with SGA, and the association between free β-hCG < 0.3 MoM and SGA was as strong as that between PAPP-A < 0.3 MoM and SGA (OR, 3.1 and 3.0, respectively). CONCLUSION: The combination of slow early fetal growth and low PAPP-A resulted in a nearly six-fold increased risk of delivery of an SGA infant. These findings might improve our chances of early identification of fetuses at increased risk of growth restriction. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
| | |
Authors:
|
I Kirkegaard; T B Henriksen; N Uldbjerg |
Related Documents
:
|
19838805 - Outcome of gonadotropin therapy for male infertility due to hypogonadotrophic hypogonad... 19716535 - The efficiency of first-trimester serum analytes and maternal characteristics in predic... 3872425 - In vivo and in vitro studies on the production of placental proteins (human chorionic g... 11800885 - High-confinement regime at high beta(n) values due to a changed behavior of the neoclas... 8233275 - Uterine artery doppler velocity waveforms in twin pregnancies. 3107205 - Effect of pcb on some mfo enzyme activities in pregnant and virgin rabbits. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 37 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
|
Languages: eng Pagination: 341-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark; Perinatal Epidemiology Research Unit, Aarhus University Hospital, Aarhus, Denmark. ida.kirkegaard@ki.au.dk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-guided tru-cut biopsy of abdominal and pelvic tumors in gynecology.
Next Document: Prenatal diagnosis of fetal left pulmonary artery sling.