Document Detail

Early fetal cystoscopy for first-trimester severe megacystis.
MedLine Citation:
PMID:  21337440     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To report the feasibility of early fetal cystoscopy for the prenatal diagnosis and therapy of severe first-trimester megacystis. METHODS: Between January 2008 and February 2010, early fetal cystoscopy at 16 weeks of gestation was offered to 15 patients whose fetuses presented with severe first-trimester megacystis. All infants were followed 6-12 months after birth. Autopsy was always performed whenever fetal or neonatal deaths occurred. RESULTS: Seven patients decided to undergo fetal therapy and 8 elected to continue with expectant observation. One fetus died before early fetal cystoscopy. Therefore, six fetuses underwent early fetal cystoscopy, in which one had postnatal diagnosis of megacystis-microcolon intestinal hypoperistalsis syndrome (both died neonatally). Urethral atresia, which was diagnosed in three fetuses during fetal cystoscopy and confirmed at autopsy, was associated with bad outcome. Posterior urethral valves were diagnosed and successfully fulgurated by laser during early cystoscopy in two fetuses, who survived with normal renal and bladder functions after birth. In the expectant group, no survivals were observed even among cases with "isolated" posterior urethral valves. CONCLUSIONS: Percutaneous early fetal cystoscopy is feasible for prenatal diagnosis and therapy of severe megacystis. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Rodrigo Ruano; Carlos Tadashi Yoshisaki; Eugenia Maria Assunção Salustiano; Amilcar Martins Giron; Miguel Srougi; Marcelo Zugaib
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Obstetrics Department, Faculty of Medicine, São Paulo University, São Paulo, Brazil.
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