Document Detail

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy.
MedLine Citation:
PMID:  20541249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The diversity in the perceived prevalence, recovery, and risk factors for cow's milk allergy (CMA) necessitated a large-scale, population-based prospective study.
OBJECTIVE: We sought to determine the prevalence, cross-reactivity with soy allergy, and risk factors for the development of CMA.
METHODS: In a prospective study the feeding history of 13,019 infants was obtained by means of telephone interview (95.8%) or questionnaire (4.2%). Infants with probable adverse reactions to milk were examined, skin prick tested, and challenged orally.
RESULTS: Ninety-eight percent of the cohort participated in the study. The cumulative incidence for IgE-mediated CMA was 0.5% (66/13,019 patients). The mean age of cow's milk protein (CMP) introduction was significantly different (P < .001) between the healthy infants (61.6 +/- 92.5 days) and those with IgE-mediated CMA (116.1 +/- 64.9 days). Only 0.05% of the infants who were started on regular CMP formula within the first 14 days versus 1.75% who were started on formula between the ages of 105 and 194 days had IgE-mediated CMA (P < .001). The odds ratio was 19.3 (95% CI, 6.0-62.1) for development of IgE-mediated CMA among infants with exposure to CMP at the age of 15 days or more (P < .001). Sixty-four patients with IgE-mediated CMA tolerated soy, and none had a proved allergy to soy.
CONCLUSIONS: IgE-mediated CMA is much less common than generally reported. Early exposure to CMP as a supplement to breast-feeding might promote tolerance. Finally, soy is a reasonable feeding alternative in patients with IgE-mediated CMA.
Yitzhak Katz; Nelly Rajuan; Michael R Goldberg; Eli Eisenberg; Eli Heyman; Adi Cohen; Moshe Leshno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-11
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-07-30     Revised Date:  2011-04-14    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Allergy and Immunology Institute, Assaf-Harofeh Medical Center, Zerifin, Israel.
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MeSH Terms
Breast Feeding
Immunoglobulin E / immunology*
Infant, Newborn
Milk Hypersensitivity / prevention & control*
Milk Proteins / immunology*
Prospective Studies
Risk Factors
Soybeans / immunology
Reg. No./Substance:
0/Milk Proteins; 37341-29-0/Immunoglobulin E
Comment In:
J Allergy Clin Immunol. 2011 Mar;127(3):836-8; author reply 839-40   [PMID:  21281962 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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