| Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. | |
| | |
MedLine Citation:
|
PMID: 20541249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The diversity in the perceived prevalence, recovery, and risk factors for cow's milk allergy (CMA) necessitated a large-scale, population-based prospective study. OBJECTIVE: We sought to determine the prevalence, cross-reactivity with soy allergy, and risk factors for the development of CMA. METHODS: In a prospective study the feeding history of 13,019 infants was obtained by means of telephone interview (95.8%) or questionnaire (4.2%). Infants with probable adverse reactions to milk were examined, skin prick tested, and challenged orally. RESULTS: Ninety-eight percent of the cohort participated in the study. The cumulative incidence for IgE-mediated CMA was 0.5% (66/13,019 patients). The mean age of cow's milk protein (CMP) introduction was significantly different (P < .001) between the healthy infants (61.6 +/- 92.5 days) and those with IgE-mediated CMA (116.1 +/- 64.9 days). Only 0.05% of the infants who were started on regular CMP formula within the first 14 days versus 1.75% who were started on formula between the ages of 105 and 194 days had IgE-mediated CMA (P < .001). The odds ratio was 19.3 (95% CI, 6.0-62.1) for development of IgE-mediated CMA among infants with exposure to CMP at the age of 15 days or more (P < .001). Sixty-four patients with IgE-mediated CMA tolerated soy, and none had a proved allergy to soy. CONCLUSIONS: IgE-mediated CMA is much less common than generally reported. Early exposure to CMP as a supplement to breast-feeding might promote tolerance. Finally, soy is a reasonable feeding alternative in patients with IgE-mediated CMA. |
| | |
Authors:
|
Yitzhak Katz; Nelly Rajuan; Michael R Goldberg; Eli Eisenberg; Eli Heyman; Adi Cohen; Moshe Leshno |
Related Documents
:
|
34919 - Bruising and muscle ph with mixing groups of cattle pre-transport. 3325469 - Prevalence of postenteritis cow's milk protein intolerance. 2088099 - Prevention of allergic diseases and ige dosification in cord sera. 3929969 - Egg and cows' milk hypersensitivity in exclusively breast fed infants with eczema, and ... 8045809 - Amaranthus retroflexus (redroot pigweed) poisoning in cattle. 2295949 - Cow milk feeding in infancy: further observations on blood loss from the gastrointestin... 7258549 - Frequency of tuberous sclerosis in san-in district (japan) and birth weight of patients... 17883879 - Malaria-related mortality based on verbal autopsy in an area of low endemicity in a pre... 6587719 - Hypertension in pregnancy and the infant. a controlled follow-up study. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-11 |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: 126 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-12 Completed Date: 2010-07-30 Revised Date: 2011-04-14 |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 77-82.e1 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Allergy and Immunology Institute, Assaf-Harofeh Medical Center, Zerifin, Israel. ykatz49@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Breast Feeding Cattle Female Humans Immunoglobulin E / immunology* Infant Infant, Newborn Male Milk Hypersensitivity / prevention & control* Milk Proteins / immunology* Prospective Studies Risk Factors Soybeans / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Milk Proteins; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
Comment In:
|
J Allergy Clin Immunol. 2011 Mar;127(3):836-8; author reply 839-40
[PMID:
21281962
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.
Next Document: Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 ...