Document Detail


Early experience with the use of anti-inhibitor coagulant complex to treat bleeding in hemophiliacs with inhibitors to factor VIII.
MedLine Citation:
PMID:  3111706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early clinical experience with anti-inhibitor coagulant complex in the treatment of bleeding in patients with factor VIII inhibitors is described. Sixty patients with a total of 120 bleeding episodes were studied. Satisfactory responses were obtained in 86.6% of bleeding episodes. Efficacy was slightly better in open bleeding than in closed bleeding. Higher doses were significantly better than lower doses in treating open bleeding. The incidence of adverse reactions was low. The results reported support the safety and efficacy of anti-inhibitor coagulant complex in the treatment of bleeding in patients with factor VIII inhibitors.
Authors:
J L Kantrowitz; M L Lee; D A McClure; H S Kingdon; W R Thomas
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  9     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-11     Completed Date:  1987-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Coagulation Tests
Child
Child, Preschool
Clinical Trials as Topic
Factor IX / therapeutic use*
Factor IXa
Factor VIII / antagonists & inhibitors*
Female
Hemophilia A / blood,  therapy*
Humans
Infant
Male
Middle Aged
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX; EC 3.4.21.22/Factor IXa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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