| Early experience with the use of anti-inhibitor coagulant complex to treat bleeding in hemophiliacs with inhibitors to factor VIII. | |
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MedLine Citation:
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PMID: 3111706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early clinical experience with anti-inhibitor coagulant complex in the treatment of bleeding in patients with factor VIII inhibitors is described. Sixty patients with a total of 120 bleeding episodes were studied. Satisfactory responses were obtained in 86.6% of bleeding episodes. Efficacy was slightly better in open bleeding than in closed bleeding. Higher doses were significantly better than lower doses in treating open bleeding. The incidence of adverse reactions was low. The results reported support the safety and efficacy of anti-inhibitor coagulant complex in the treatment of bleeding in patients with factor VIII inhibitors. |
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Authors:
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J L Kantrowitz; M L Lee; D A McClure; H S Kingdon; W R Thomas |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 9 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1987 |
Date Detail:
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Created Date: 1987-09-11 Completed Date: 1987-09-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-19 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Blood Coagulation Tests Child Child, Preschool Clinical Trials as Topic Factor IX / therapeutic use* Factor IXa Factor VIII / antagonists & inhibitors* Female Hemophilia A / blood, therapy* Humans Infant Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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9001-27-8/Factor VIII; 9001-28-9/Factor IX; EC 3.4.21.22/Factor IXa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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