| Early experience with magnesium administration in Irukandji syndrome. | |
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MedLine Citation:
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PMID: 15535491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The administration of magnesium sulphate is a proposed novel therapy for Irukandji syndrome'. In this non-randomized, unblinded case series, data from ten patients who received magnesium salts are reviewed. Magnesium sulphate boluses of 10 to 20 mmol, in the six patients for which there was adequate data, reduced pain scores immediately after administration from 8.7+/-1.5 to 2.8+/-2.8 (Wilcoxon rank-sum test, P=0.03). In ten patients blood pressure decreased with a mean difference of -18 mmHg in mean arterial pressure. Magnesium requirements in individual patients varied markedly. Pain on injection occurred in four patients, three of whom had received peripherally administered magnesium chloride, and one patient reported transient ptosis after administration of magnesium sulphate 166 mmol over 18 hours in the setting of severe Irukandji syndrome. Magnesium sulphate administration appears to attenuate pain and hypertension in Irukandji syndrome and warrants further evaluation in this setting. |
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Authors:
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M Corkeron; P Pereira; C Makrocanis |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 32 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-10 Completed Date: 2005-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 666-9 Citation Subset: IM |
Affiliation:
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Intensive Care Unit, The Townsville Hospital, Queensland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Australia Bites and Stings / complications* Cnidarian Venoms* Cubozoa* Drug Administration Schedule Female Humans Infusions, Intravenous Magnesium Sulfate / therapeutic use* Male Pain / drug therapy*, etiology Pain Measurement Prospective Studies Risk Assessment Sampling Studies Syndrome Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cnidarian Venoms; 7487-88-9/Magnesium Sulfate |
| Comments/Corrections | |
Comment In:
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Anaesth Intensive Care. 2005 Aug;33(4):541-2
[PMID:
16119507
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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