Document Detail


Early evolution from ischemia to myocardial necrosis.
MedLine Citation:
PMID:  12213977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence, age, and extent of myocardial ischemic injury can be determined with some precision using pathologic techniques. Electron microscopic studies can detect very early ischemic injury, only minutes old, even before irreversible injury (i.e., necrosis) is present; however, because of the small amount of tissue sampled, ultrastructural studies are not very useful for quantifying the size of the ischemic zone. Histologic studies can detect irreversible injury only hours old, and because large samples can be studied, the necrotic zone can be measured quite efficiently. In addition, the age of the infarct can be determined. The knowledge gleaned from such morphologic studies continues to contribute to the development of new diagnostic tests and therapies for patients with ischemic heart disease.
Authors:
M C Fishbein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular toxicology     Volume:  1     ISSN:  1530-7905     ISO Abbreviation:  Cardiovasc. Toxicol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-09-05     Completed Date:  2002-10-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101135818     Medline TA:  Cardiovasc Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
UCLA School of Medicine, Los Angeles, CA 90095, USA. mfishbein@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Disease Progression
Humans
Myocardial Ischemia / metabolism,  pathology*
Myocardium / pathology,  ultrastructure
Necrosis

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