| Early events in HSV keratitis--setting the stage for a blinding disease. | |
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MedLine Citation:
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PMID: 15857807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The last decade has seen herpes simplex virus (HSV)-induced stromal keratitis (SK) research shift from being a topic only of interest to vision researchers to one that fascinates the general field of inflammatory disease. Studies on experimental mouse lesions have uncovered several fundamental processes that explain lesion development. In this model, the chronic immuno-inflammatory lesions are mainly orchestrated by CD4+ T cells, but multiple early events occur that set the stage for the subsequent pathology. These include virus replication, the production of key cytokines and chemokines, neovascularization of the avascular cornea and the influx of certain inflammatory cell types. Many of these early events are subject to modulation, providing an approach to controlling this important cause of human blindness. We also comment on events ongoing during chronic SK, debating whether or not these represent virus-induced or autoimmune lesions. |
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Authors:
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Partha S Biswas; Barry T Rouse |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review Date: 2005-03-22 |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: 7 ISSN: 1286-4579 ISO Abbreviation: Microbes Infect. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-05-23 Completed Date: 2005-07-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: France |
Other Details:
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Languages: eng Pagination: 799-810 Citation Subset: IM |
Affiliation:
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Comaprative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37916, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blindness / etiology* Cornea / virology Disease Models, Animal Herpesvirus 1, Human / pathogenicity* Humans Keratitis, Herpetic / complications*, immunology, physiopathology*, virology Mice |
| Grant Support | |
ID/Acronym/Agency:
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EY05093/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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