| Early electrocardiographic evaluation of atrial fibrillation risk in beta-thalassemia major patients. | |
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MedLine Citation:
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PMID: 21512730 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and diastolic functions. The study involved 40 β-TM patients (age 37.5 ± 10.2; 33 M) and 40 healthy subjects used as controls, matched for age and gender. PD was carefully measured using a 12-lead electrocardiogram. Cardiac iron levels were measured by cardiac magnetic resonance T2 star (CMR T2*) imaging. Comparing to the healthy control group, β-TM group presented increased values of the PD (40.1 ± 12.9 vs. 24 ± 7 ms; P < 0.004) and decreased CMR T2* imaging (29 ± 15 vs. 55 ± 13 ms; P = 0.03). We found a significant correlation between PD and CMR T2* values. Our study showed a significant increase of PD in β-TM patients with conserved systolic and diastolic cardiac functions. Our results indicate that PD is correlated to myocardial iron deposit, as assessed by CMR T2* imaging. |
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Authors:
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Vincenzo Russo; Anna Rago; Bruno Pannone; Federica Di Meo; Andrea Antonio Papa; Maria Carolina Mayer; Anna Spasiano; Maria Giovanna Russo; Paolo Golino; Raffaele Calabrò; Gerardo Nigro |
Publication Detail:
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Type: Journal Article Date: 2011-03-10 |
Journal Detail:
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Title: International journal of hematology Volume: 93 ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Japan |
Other Details:
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Languages: eng Pagination: 446-51 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Second University of Naples, Via Leonardo Bianchi, 80100, Naples, Italy, v.p.russo@libero.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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