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Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study.
MedLine Citation:
PMID:  25305703     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: We examined whether early loading of eicosapentaenoic acid (EPA) reduces clinical adverse events by 1month, accompanied by a decrease in C-reactive protein (CRP) values in patients with acute myocardial infarction (MI).
BACKGROUND: Acute MI triggers an inflammatory reaction, which plays an important role in myocardial injury. EPA could attenuate the inflammatory response.
METHODS: This prospective, open-label, blinded endpoint, randomized trial consisted of 115 patients with acute MI. They were randomly assigned to the EPA group (57 patients) and the control group (58 patients). After percutaneous coronary intervention (PCI), 1800mg/day of EPA was initiated within 24h. The primary endpoint was composite events, including cardiac death, stroke, re-infarction, ventricular arrhythmias, and paroxysmal atrial fibrillation within 1month.
RESULTS: Administration of EPA significantly reduced the primary endpoint within 1month (10.5 vs 29.3%, p=0.01), especially the incidence of ventricular arrhythmias (7.0 vs 20.6%, p=0.03). Peak CRP values after PCI in the EPA group were significantly lower than those in the control group (median [interquartile range], 8.2 [5.6-10.2] mg/dl vs 9.7 [7.6-13.9] mg/dl, p<0.01). Logistic regression analysis showed that EPA use was an independent factor related to ventricular arrhythmia until 1month, with an odds ratio of 0.29 (95% confidence interval, 0.09 to 0.96, p=0.04).
CONCLUSIONS: Early EPA treatment after PCI in the acute stage of MI reduces the incidence of ventricular arrhythmias, and lowers CRP values.
Masayuki Doi; Kazumasa Nosaka; Toru Miyoshi; Mutsumi Iwamoto; Masahito Kajiya; Keisuke Okawa; Rie Nakayama; Wataru Takagi; Ko Takeda; Satoshi Hirohata; Hiroshi Ito
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Publication Detail:
Type:  Journal Article     Date:  2014-08-19
Journal Detail:
Title:  International journal of cardiology     Volume:  176     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  577-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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