Document Detail


Early disappearance of lymphatics draining ischemic myocardium in the dog.
MedLine Citation:
PMID:  3813124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess myocardial lymphatics during the evolution of myocardial infarction we performed lymphangiographic studies thirty and three hundred sixty minutes after occlusion of the left anterior descending coronary artery in 92 dogs. A morphometric index was employed on a coded basis to assess the lymphangiograms. Well before myocardial necrosis was evident, at thirty minutes, a striking reduction was evident in lymphatic filling in the ischemic zone: similar changes were seen three hundred sixty minutes after occlusion. Heparin in doses that rendered blood incoagulable did not prevent the lymphatic occlusion or collapse, but they were prevented by two agents that act as cardiac lymphagogues, hyaluronidase and CLS 2210. Lymph flow from the heart was assessed in another 23 dogs. Lymph flow fell sharply after coronary artery occlusion in placebo-treated dogs but was well maintained in dogs treated with hyaluronidase and with CLS 2210. The reduction in cardiac lymphatic filling and lymph flow occurred too early to be a consequence of myocardial necrosis. To the extent that reduced lymphatic drainage allows the local accumulation of potentially toxic products, it could contribute to the local damage. Treatment with the lymphagogues not only maintained lymphatic patency but also reduced evidence of myocardial damage evident on examination by light and electron microscopy. These studies provide an alternative to commonly held concepts on how hyaluronidase reduces myocardial infarction after coronary artery occlusion and support the concept that lymphatic occlusion or collapse plays a role in myocardial infarction.
Authors:
L Szlavy; K Koster; A de Courten; N K Hollenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Angiology     Volume:  38     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-84     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzenesulfonates / therapeutic use
Dogs
Female
Heart / radiography
Heparin / therapeutic use
Hyaluronoglucosaminidase / therapeutic use
Lymph / physiology
Lymphatic System / drug effects,  pathology,  physiopathology*
Lymphography
Male
Myocardial Infarction / drug therapy,  pathology,  physiopathology*,  radiography
Grant Support
ID/Acronym/Agency:
GM 18674/GM/NIGMS NIH HHS; HL 05832/HL/NHLBI NIH HHS; HL 20895/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Benzenesulfonates; 9005-49-6/Heparin; 99270-13-0/CLS 2210; EC 3.2.1.35/Hyaluronoglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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