Document Detail

Early differentiation of cardioembolic from atherothrombotic cerebral infarction: a multivariate analysis.
MedLine Citation:
PMID:  10529755     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine factors predictive of cerebral infarction subtype from clinical data collected within 48 h of neurologic deficit. All cardioembolic (n = 231) and atherothrombotic infarctions (n = 369) included in prospective stroke registry of the Sagrat Cor-Alianza Hospital of Barcelona were analysed. Demographic characteristics, anamnestic findings, cerebrovascular risk factors and clinical data of patients with embolic stroke and patients with thrombotic infarction were compared. Predictors of stroke subtype were assessed by means of a logistic regression model based on 16 clinical variables. After multivariate analysis, atrial dysrhythmia and sudden onset to maximal deficit were significant predictors of embolic stroke, whereas hypertension, chronic obstructive pulmonary disease, diabetes, hypercholesterolemia and/or hypertriglyceridemia and age were independent predictive factors of atherothrombotic stroke. Setting a cut-off point of 0.50 for predicting mechanism of stroke on admission resulted in a sensitivity of 76%, specificity of 87% and total correct classification of 83%. Clinical features alone that are observed at stroke onset can help to distinguish cardioembolic from atherothrombotic infarctions.
A Arboix; M Oliveres; J Massons; R Pujades; L Garcia-Eroles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  6     ISSN:  1351-5101     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-06-23     Completed Date:  2000-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Lippincott Williams & Wilkins
Acute Stroke Unit, Department of Neurology, Hospital del Sagrat Cor, Barcelona, Spain.
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MeSH Terms
Cerebral Infarction / epidemiology*
Heart Diseases / complications*,  epidemiology*
Intracranial Embolism / epidemiology*,  etiology*
Multivariate Analysis
Prospective Studies
Risk Factors
Thrombosis / epidemiology*,  etiology*
Time Factors

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