Document Detail


Early diagnosis of fat embolism syndrome by automated image analysis of alveolar macrophages.
MedLine Citation:
PMID:  8027755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the value of automated semiquantitative analysis of fat within alveolar macrophages as an early diagnostic tool for fat embolism syndrome (FES), we investigated 3 patients with respiratory failure following long-bone fractures. The mean area of fat droplets per alveolar macrophage was determined in pixels and, additionally, the percentage of the evaluated areas was calculated. In 2 patients, the diagnosis of FES could be established as early as 24 hr after trauma. Both patients showed an increase in the area of fat per alveolar macrophage (pixels: 851, 1069) as well as in the percentage of fat area per alveolar macrophage area (40.04%, 52.73%), whereas the analysis of the bronchoalveolar lavage (BAL) specimens of a third patient, who later recovered without appearance of clinical signs of FES, revealed only minimal fat content (pixels: 82; 3.82%). Automated semiquantitative analysis of fat within alveolar macrophages may be helpful in the early diagnosis of FES.
Authors:
A Benzer; D Ofner; M Tötsch; G Klima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical monitoring     Volume:  10     ISSN:  0748-1977     ISO Abbreviation:  J Clin Monit     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-08-09     Completed Date:  1994-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506707     Medline TA:  J Clin Monit     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-5     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, University Hospital of Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Embolism, Fat / diagnosis*,  etiology
Fractures, Bone / complications
Humans
Image Processing, Computer-Assisted*
Lipids / analysis
Macrophages, Alveolar / chemistry,  pathology*
Chemical
Reg. No./Substance:
0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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