| Early diagnosis of chemotherapy-induced cardiomyopathy: a prospective tissue Doppler imaging study. | |
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MedLine Citation:
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PMID: 18347931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to compare the applicability of the conventional echocardiography and a novel method, tissue Doppler imaging (TDI) in detection of late or subclinical cardiotoxicity following anthracycline chemotherapy in long-term follow up. Forty women (31 to 65 years) were enrolled, who had not received anthracyclines previously and had normal cardiac function. The control group consisted of 20 healthy persons of similar age range. In addition to standard echocardiographic measurements, each patient underwent specific measurements (E-septum separation, pulmonary venous flow) as well. Furthermore, the myocardial velocity of numerous segments of the mitral anulus obtained with pulsed wave TDI was also detected over a two-year-long period. Systolic left ventricular function did not change significantly either in the study or in the control group. After one year, diastolic left ventricular function was impaired in 39 patients (97.5%), and 29 (72.5%) of these showed clear changes by means of the traditional E/A ratio and TDI. However, in ten patients (25%) the diastolic dysfunction could only be detected with TDI. At the end of the study diastolic dysfunction was detected in each patient, but in 13 patients (32.5%) the relaxation disorder could be revealed only with TDI. Detectable myocardial damage occurred in the study group as a result of anthracycline therapy. Our results confirmed our assumptions that TDI is a more precise and useful examination method than the traditional ones (E/A ratio or deceleration time) to demonstrate isolated diastolic dysfunction. TDI may become a regularly and more widely used noninvasive method to detect subclinical cardiotoxicity emerging after chemotherapy. |
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Authors:
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András Csaba Nagy; Zsuzsanna Cserép; Edina Tolnay; Tamás Nagykálnai; Tamás Forster |
Publication Detail:
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Type: Journal Article Date: 2008-03-15 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: 14 ISSN: 1219-4956 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-05-30 Completed Date: 2009-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 69-77 Citation Subset: IM |
Affiliation:
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1st Department of Internal Medicine and Cardiology, Uzsoki Municipal Hospital, Uzsoki u. 29, Budapest H-1145, Hungary. nagycsaba@uzsoki.hu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anthracyclines / adverse effects*, therapeutic use Antibiotics, Antineoplastic / adverse effects*, therapeutic use Breast Neoplasms / drug therapy Cardiomyopathies / chemically induced*, diagnosis Early Diagnosis Echocardiography Echocardiography, Doppler* Female Follow-Up Studies Heart / physiopathology Humans Middle Aged Statistics, Nonparametric Ventricular Dysfunction, Left / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Anthracyclines; 0/Antibiotics, Antineoplastic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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