| Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media. | |
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MedLine Citation:
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PMID: 17350198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wegener's granulomatosis (WG) is a multi-system disease characterized by granuloma formation and widespread necrotizing vasculitis. It classically presents with involvement of the upper and lower respiratory tracts and renal system. Facial nerve palsy and otologic manifestations have been reported during the course of the disease but it is extremely rare as the presenting features. In Literature only one case of bilateral facial palsy as presenting sign of WG is reported. The testing of anticytoplasmic antibodies versus neutrophil polymorphonucleate granules (c-ANCA) are highly specific for the diagnosis of WG, being positive in 97% of the cases. The early diagnosis and the timely medical treatment lead to high rates of remission of an otherwise lethal disease. A case of WG presenting with bilateral facial paralysis and bilateral serous otitis media is reported. |
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Authors:
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Emanuele Ferri; Enrico Armato; Paolo Capuzzo; Stefano Cavaleri; Ferdinando Ianniello |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-09 |
Journal Detail:
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Title: Auris, nasus, larynx Volume: 34 ISSN: 0385-8146 ISO Abbreviation: Auris Nasus Larynx Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-06-04 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708170 Medline TA: Auris Nasus Larynx Country: Netherlands |
Other Details:
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Languages: eng Pagination: 379-82 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, General Hospital of Dolo, Riviera XXIX Aprile, 2, 30031 DOLO, Venice, Italy. emaferri@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Antibodies, Antineutrophil Cytoplasmic / blood Cyclophosphamide / therapeutic use Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Facial Paralysis / diagnosis, etiology* Female Hearing Loss, Mixed Conductive-Sensorineural / diagnosis, etiology Humans Immunosuppressive Agents / therapeutic use Middle Aged Otitis Media with Effusion / diagnosis, etiology* Prednisolone / therapeutic use Tomography, X-Ray Computed Wegener Granulomatosis / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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