Document Detail


Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media.
MedLine Citation:
PMID:  17350198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wegener's granulomatosis (WG) is a multi-system disease characterized by granuloma formation and widespread necrotizing vasculitis. It classically presents with involvement of the upper and lower respiratory tracts and renal system. Facial nerve palsy and otologic manifestations have been reported during the course of the disease but it is extremely rare as the presenting features. In Literature only one case of bilateral facial palsy as presenting sign of WG is reported. The testing of anticytoplasmic antibodies versus neutrophil polymorphonucleate granules (c-ANCA) are highly specific for the diagnosis of WG, being positive in 97% of the cases. The early diagnosis and the timely medical treatment lead to high rates of remission of an otherwise lethal disease. A case of WG presenting with bilateral facial paralysis and bilateral serous otitis media is reported.
Authors:
Emanuele Ferri; Enrico Armato; Paolo Capuzzo; Stefano Cavaleri; Ferdinando Ianniello
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-09
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  34     ISSN:  0385-8146     ISO Abbreviation:  Auris Nasus Larynx     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, General Hospital of Dolo, Riviera XXIX Aprile, 2, 30031 DOLO, Venice, Italy. emaferri@libero.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Antibodies, Antineutrophil Cytoplasmic / blood
Cyclophosphamide / therapeutic use
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Facial Paralysis / diagnosis,  etiology*
Female
Hearing Loss, Mixed Conductive-Sensorineural / diagnosis,  etiology
Humans
Immunosuppressive Agents / therapeutic use
Middle Aged
Otitis Media with Effusion / diagnosis,  etiology*
Prednisolone / therapeutic use
Tomography, X-Ray Computed
Wegener Granulomatosis / diagnosis*
Chemical
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone

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