Document Detail

Early developmental outcome of infants with infantile hypertrophic pyloric stenosis.
MedLine Citation:
PMID:  21129547     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The study aimed to compare the developmental outcome of infants with infantile hypertrophic pyloric stenosis (IHPS) who underwent pyloromyotomy with healthy control infants in New South Wales (NSW), Australia.
METHODS: Infants diagnosed with IHPS requiring surgical intervention were enrolled prospectively between August 1, 2006, and July 31, 2008. Healthy control infants were enrolled in the same period. The children underwent a developmental assessment at 1 year of age (corrected) using the Bayley Scales of Infant and Toddler Development (Version III).
RESULTS: Of 52 infants with IHPS who were enrolled, 43 had developmental assessments. Most (90.6%) were term infants (>36 weeks gestation) with a median birth weight of 3237.8 g. Two infants (8%) had an associated birth defect, and survival was 100%. Developmental assessments were also performed on 211 control infants. Infants with IHPS scored significantly lower on the cognitive, receptive language, fine motor, and gross motor subscales compared to the control infants.
CONCLUSIONS: This unique study found lower than expected developmental scores for infants after surgery for IHPS than for healthy control infants. These findings raise concerns over the potential impact of IHPS and its surgical treatment. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed.
Karen Walker; Robert Halliday; Andrew J A Holland; Caroline Karskens; Nadia Badawi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  45     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-04-08     Revised Date:  2011-08-08    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2369-72     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.
Grace Centre for Newborn Care, The Children's Hospital at Westmead, Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, New South Wales 2145, Australia.
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MeSH Terms
Developmental Disabilities / epidemiology*,  etiology
Follow-Up Studies
Gestational Age
Infant, Newborn
Language Development Disorders / epidemiology*,  etiology
Motor Skills Disorders / epidemiology*,  etiology
New South Wales / epidemiology
Postoperative Complications / epidemiology,  etiology
Prospective Studies
Pyloric Stenosis, Hypertrophic / epidemiology*,  psychology,  surgery
Sample Size
Severity of Illness Index
Comment In:
J Pediatr Surg. 2011 Jun;46(6):1298-9; author reply 1299   [PMID:  21683243 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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