| Early development of the retinal line of decussation in normal and albino ferrets. | |
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MedLine Citation:
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PMID: 1748727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work describes the retinal origin of the crossed and uncrossed projections in newborn, 9-day-old and adult normally pigmented and albino ferrets. Horseradish peroxidase (HRP) was injected unilaterally into the thalamic and midbrain visual centers of ferrets to label retinal ganglion cells retrogradely. In normally pigmented adults, the retinal line of decussation was sharp and passed through the area centralis. Ganglion cells with uncrossed axons occupied the entire temporal retina. In albino adults, ganglion cells with uncrossed axons were distributed in the periphery of the temporal retina away from the area centralis. In the normally pigmented adults, about 11% of the retinal ganglion cells had uncrossed axons compared to about 4% in the albinos. At birth, normally pigmented ferrets had a sharp line of decussation with most (about 98%) uncrossed ganglion cells found in the temporal retina. In the newborn albinos, most uncrossed ganglion cells were in the temporal retina (about 89%), but there were many fewer than in the normal neonates and, as in the albino adults, the uncrossed ganglion cells were distributed along the temporal most margin of the retina. In the normal neonates, about 11% of the ganglion cells had uncrossed axons, compared to about 3% in the albino neonates. The area centralis and visual streak were not evident until 9 days after birth. From these results we conclude that the retinal line of decussation is essentially mature by birth in the ferret, and the degree of the albino's abnormality is as extreme in neonates as in adults. The retinal decussation is virtually mature at a stage of development when the crossed and uncrossed retinal afferent axons are completely intermingled in their target nuclei and prior to the onset of significant retinal ganglion cell loss. |
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Authors:
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J B Cucchiaro |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of comparative neurology Volume: 312 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-01-21 Completed Date: 1992-01-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-206 Citation Subset: IM |
Affiliation:
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Committee on Neurobiology, University of Chicago, Illinois 60637. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,3'-Diaminobenzidine Albinism / physiopathology* Animals Animals, Newborn / growth & development* Cell Count Ferrets / growth & development* Horseradish Peroxidase Reference Values Retina / cytology, growth & development* Retinal Ganglion Cells / cytology |
| Grant Support | |
ID/Acronym/Agency:
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EYO2374/EY/NEI NIH HHS; EYO3604/EY/NEI NIH HHS; GM-07839/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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91-95-2/3,3'-Diaminobenzidine; EC 1.11.1.-/Horseradish Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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