Document Detail

Early development of osteoporosis in male smokers with hypoandrogenism due to fascioliasis with or without schistosomiasis added by life style.
MedLine Citation:
PMID:  20120745     Owner:  NLM     Status:  MEDLINE    
The multifactor outcome of hypoandrogenemia with the impact of oxidative stress induced by glucose intolerance, fascioliasis with or without schistosomiasis and cumulative smoking influence on bone remodeling and the early development of osteoporotic manifestations were studied. The effect on vascular endothelium immune mediated mechanisms and antioxidant capacity were monitored in cases of youth aged selected male smokers involving 20 with hypoandrogenemia who were either subjected to sedentary life style, glucose intolerance fascioliasis hepatic fibrosis (FHF) (G1) or without (G2) and GI after following 6 months therapy (G3). Monitoring of clinical picture and biochemical assessments of osteoporotic indices (osteocolcin, bone alkaline phosphatase, parathyroid hormone, urinary cyclic AMP), hypoandrogenism (dehydroepiandrosterane sulphate or DHEAS & testosterone) glycemic determinant (insulin) immuno-inflammatory response (interleukein-6, tumor necrosis factor alpha, E-selectin, ceruloplasmin) smoking index (serum cotinine), total antioxidant capacity (AOC) and lipid peroxidation (malonedialdehyde) was done before and after 6 months therapeutic program involving supplement of DHEAS, mirazid, chromium picolinate, and megavit zinc alongside smoking cessation and physical exercise daily for at least 30 minutes. Treatment with Mirazid supplied as 10 mg/kg for 6 successive days resulted in 100% cure of fascioliasis whether single or combined with schistosomiasis.
Yasser Fouad Kilany; Sahar A Abou Holw; Mohamed Fathy Abouel-Nour; Ayman T A Morsy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Egyptian Society of Parasitology     Volume:  39     ISSN:  1110-0583     ISO Abbreviation:  J Egypt Soc Parasitol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-02-23     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8102141     Medline TA:  J Egypt Soc Parasitol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  789-802     Citation Subset:  IM    
Department of Tropical Medicine, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
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MeSH Terms
Androgens / blood
Anthelmintics / therapeutic use
Antioxidants / metabolism
Commiphora / chemistry
Egypt / epidemiology
Fascioliasis / drug therapy,  epidemiology*,  metabolism
Glucose / metabolism
Hypogonadism / epidemiology*,  metabolism
Life Style
Osteoporosis / epidemiology*,  metabolism
Oxidative Stress
Plant Extracts / therapeutic use
Schistosomiasis / drug therapy,  epidemiology*,  metabolism
Smoking / adverse effects*
Reg. No./Substance:
0/Androgens; 0/Anthelmintics; 0/Antioxidants; 0/Plant Extracts; 50-99-7/Glucose

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