| Early development of osteoporosis in male smokers with hypoandrogenism due to fascioliasis with or without schistosomiasis added by life style. | |
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MedLine Citation:
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PMID: 20120745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The multifactor outcome of hypoandrogenemia with the impact of oxidative stress induced by glucose intolerance, fascioliasis with or without schistosomiasis and cumulative smoking influence on bone remodeling and the early development of osteoporotic manifestations were studied. The effect on vascular endothelium immune mediated mechanisms and antioxidant capacity were monitored in cases of youth aged selected male smokers involving 20 with hypoandrogenemia who were either subjected to sedentary life style, glucose intolerance fascioliasis hepatic fibrosis (FHF) (G1) or without (G2) and GI after following 6 months therapy (G3). Monitoring of clinical picture and biochemical assessments of osteoporotic indices (osteocolcin, bone alkaline phosphatase, parathyroid hormone, urinary cyclic AMP), hypoandrogenism (dehydroepiandrosterane sulphate or DHEAS & testosterone) glycemic determinant (insulin) immuno-inflammatory response (interleukein-6, tumor necrosis factor alpha, E-selectin, ceruloplasmin) smoking index (serum cotinine), total antioxidant capacity (AOC) and lipid peroxidation (malonedialdehyde) was done before and after 6 months therapeutic program involving supplement of DHEAS, mirazid, chromium picolinate, and megavit zinc alongside smoking cessation and physical exercise daily for at least 30 minutes. Treatment with Mirazid supplied as 10 mg/kg for 6 successive days resulted in 100% cure of fascioliasis whether single or combined with schistosomiasis. |
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Authors:
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Yasser Fouad Kilany; Sahar A Abou Holw; Mohamed Fathy Abouel-Nour; Ayman T A Morsy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Egyptian Society of Parasitology Volume: 39 ISSN: 1110-0583 ISO Abbreviation: J Egypt Soc Parasitol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-02-23 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8102141 Medline TA: J Egypt Soc Parasitol Country: Egypt |
Other Details:
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Languages: eng Pagination: 789-802 Citation Subset: IM |
Affiliation:
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Department of Tropical Medicine, Faculty of Medicine, Al Azhar University, Cairo, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Androgens / blood Animals Anthelmintics / therapeutic use Antioxidants / metabolism Commiphora / chemistry Comorbidity Egypt / epidemiology Exercise Fascioliasis / drug therapy, epidemiology*, metabolism Glucose / metabolism Humans Hypogonadism / epidemiology*, metabolism Life Style Male Osteoporosis / epidemiology*, metabolism Oxidative Stress Phytotherapy Plant Extracts / therapeutic use Schistosomiasis / drug therapy, epidemiology*, metabolism Smoking / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Anthelmintics; 0/Antioxidants; 0/Plant Extracts; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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