| Early development in Dravet syndrome; visual function impairment precedes cognitive decline. | |
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MedLine Citation:
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PMID: 21109403 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Aim of the study was to describe prospectively the early neuropsychological evolution including the first pre-cognitive stages of the Severe Myoclonic Epilepsy in Infancy (SMEI) or Dravet syndrome. Five cases, four of whom since before a diagnostic evidence of the Dravet syndrome, were followed up. Full clinical assessment including developmental, visual function and behaviour assessments were serially performed. In four cases, a variable onset age of cognitive decline assessed with developmental scales was preceded some months before by an impairment of visual function; the remaining patient during all the course of follow-up till 51 months of age showed a normal development without visual impairment. A cognitive decline with variable onset was generally confirmed in Dravet syndrome. The previous early impairment of visual function seems to herald the cognitive decline and provides useful prognostic information; furthermore, it possibly suggests some clues for a better understanding of the mechanisms of cognitive deterioration in this syndrome. |
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Authors:
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Daniela Chieffo; Daniela Ricci; Giovanni Baranello; Diego Martinelli; Chiara Veredice; Donatella Lettori; Domenica Battaglia; Charlotte Dravet; Eugenio Mercuri; Francesco Guzzetta |
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Publication Detail:
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Type: Journal Article Date: 2010-11-24 |
Journal Detail:
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Title: Epilepsy research Volume: 93 ISSN: 1872-6844 ISO Abbreviation: Epilepsy Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Catholic University, Child Neurology and Psychiatry, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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