| Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration. | |
| | |
MedLine Citation:
|
PMID: 22304959 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: We studied whether magnetic resonance imaging (MRI) could be used to detect placental inflammation before the detection of irreversible tissue damage. Next, we tested whether this early detection would enable the administration of treatment (ie, interleukin-1 receptor antagonist [IL-1Ra]) in a realistic clinical time after diagnosis. STUDY DESIGN: Pregnant rats were injected intraperitoneally with lipopolysaccharide with/without delayed IL-1Ra. MRI was performed at different time after the injection, and placentas were collected for comparison. Placental inflammation was assessed by determination of the levels of inflammatory cytokines. RESULTS: Placental inflammation was detected by MRI as early as 3 hours after maternal administration of lipopolysaccharide, concomitantly to IL-1β up-regulation. This was observed before any tissue damage, which appeared only at 24 hours after the administration of lipopolysaccharide. Delayed IL-1Ra administration (after MRI diagnosis) protected the placenta, as seen by the preserved tissue integrity and limited macrophages infiltration in the placental parenchyma. CONCLUSION: These findings established a noninvasive diagnostic method for early in utero detection of placental inflammation that would allow the administration of placentoprotective intervention within a clinically relevant delay after diagnosis. |
| | |
Authors:
|
Sylvie Girard; Luc Tremblay; Martin Lepage; Guillaume Sebire |
Related Documents
:
|
15257489 - Transparent microballoon dissection in the surgical treatment of brain tumors. 9140749 - Alterations of lactate (+lipid) concentration in brain tumors with in vivo hydrogen mag... 7556299 - Validation of automated brain contour determination in normal and abnormal cerebral sin... 20416909 - A clinical and magnetic resonance spectroscopy study of a brain tumor in a patient with... 19546329 - Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic r... 20924629 - Pretreatment with a novel aquaporin 4 inhibitor, tgn-020, significantly reduces ischemi... 10624319 - Transient splenomegaly in acute pancreatitis. 15490159 - Giant fatty schmorl's nodes: ct findings in four patients. 19399539 - Three-dimensional localization of impacted teeth using magnetic resonance imaging. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
|
Laboratoire de Neurologie Pédiatrique, Département de Pédiatrie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MDCT to Guide Transcatheter Aortic Valve Replacement and Mitral Valve Repair.
Next Document: Stability of Vocational Interests After Recent Spinal Cord Injury: Comparisons Related to Sex and Ra...