Document Detail

Early detection of myocardial ischemia by myocardial free fatty acid extraction in patients with exercise-induced angina pectoris.
MedLine Citation:
PMID:  2741828     Owner:  NLM     Status:  MEDLINE    
This study investigated whether the measurement of plasma free fatty acids (FFAs) could assist in the early detection of exercise-induced myocardial ischemia. Fifteen subjects with effort angina pectoris underwent angina-limited supine bicycle ergometer exercise testing. Myocardial FFA extraction decreased significantly from 22.8 +/- 3.1% at rest to 7.7 +/- 1.5% at peak exercise (p less than 0.05). Myocardial lactate extraction showed no significant change between rest and peak exercise. After control exercise testing, 8 subjects were given a single oral dose of nilvadipine (6 mg) and then again underwent exercise testing for the same duration. Nilvadipine lessened or abolished chest pain and there was less depression of the ST segment at peak exercise. Furthermore, myocardial FFA extraction showed no significant change between rest and peak exercise after nilvadipine administration. These results suggest that myocardial FFA extraction can be used to assess the presence of exercise-induced myocardial ischemia at an earlier stage than myocardial lactate extraction.
S Kamihara; M Yokota; M Iwase; T Miyahara; H Hayashi; H Saito; S Sugiyama; T Ozawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  AIM; IM    
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
Angina Pectoris / physiopathology*
Calcium Channel Blockers / pharmacology
Chromatography, High Pressure Liquid
Coronary Disease / diagnosis*
Exercise Test*
Fatty Acids, Nonesterified / blood*
Hemodynamics / drug effects
Nifedipine / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Fatty Acids, Nonesterified; 21829-25-4/Nifedipine; 75530-68-6/nilvadipine

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