| Early detection of myocardial ischemia by myocardial free fatty acid extraction in patients with exercise-induced angina pectoris. | |
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MedLine Citation:
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PMID: 2741828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated whether the measurement of plasma free fatty acids (FFAs) could assist in the early detection of exercise-induced myocardial ischemia. Fifteen subjects with effort angina pectoris underwent angina-limited supine bicycle ergometer exercise testing. Myocardial FFA extraction decreased significantly from 22.8 +/- 3.1% at rest to 7.7 +/- 1.5% at peak exercise (p less than 0.05). Myocardial lactate extraction showed no significant change between rest and peak exercise. After control exercise testing, 8 subjects were given a single oral dose of nilvadipine (6 mg) and then again underwent exercise testing for the same duration. Nilvadipine lessened or abolished chest pain and there was less depression of the ST segment at peak exercise. Furthermore, myocardial FFA extraction showed no significant change between rest and peak exercise after nilvadipine administration. These results suggest that myocardial FFA extraction can be used to assess the presence of exercise-induced myocardial ischemia at an earlier stage than myocardial lactate extraction. |
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Authors:
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S Kamihara; M Yokota; M Iwase; T Miyahara; H Hayashi; H Saito; S Sugiyama; T Ozawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 64 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-10 Completed Date: 1989-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 180-5 Citation Subset: AIM; IM |
Affiliation:
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First Department of Internal Medicine, Nagoya University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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physiopathology* Calcium Channel Blockers / pharmacology Chromatography, High Pressure Liquid Coronary Disease / diagnosis* Exercise Test* Fatty Acids, Nonesterified / blood* Hemodynamics / drug effects Humans Nifedipine / analogs & derivatives, pharmacology Supination |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Fatty Acids, Nonesterified; 21829-25-4/Nifedipine; 75530-68-6/nilvadipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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