Document Detail


Early detection of myocardial ischemia by myocardial free fatty acid extraction in patients with exercise-induced angina pectoris.
MedLine Citation:
PMID:  2741828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated whether the measurement of plasma free fatty acids (FFAs) could assist in the early detection of exercise-induced myocardial ischemia. Fifteen subjects with effort angina pectoris underwent angina-limited supine bicycle ergometer exercise testing. Myocardial FFA extraction decreased significantly from 22.8 +/- 3.1% at rest to 7.7 +/- 1.5% at peak exercise (p less than 0.05). Myocardial lactate extraction showed no significant change between rest and peak exercise. After control exercise testing, 8 subjects were given a single oral dose of nilvadipine (6 mg) and then again underwent exercise testing for the same duration. Nilvadipine lessened or abolished chest pain and there was less depression of the ST segment at peak exercise. Furthermore, myocardial FFA extraction showed no significant change between rest and peak exercise after nilvadipine administration. These results suggest that myocardial FFA extraction can be used to assess the presence of exercise-induced myocardial ischemia at an earlier stage than myocardial lactate extraction.
Authors:
S Kamihara; M Yokota; M Iwase; T Miyahara; H Hayashi; H Saito; S Sugiyama; T Ozawa
Related Documents :
18471448 - Effect of cardiac rehabilitation on myocardial perfusion reserve in postinfarction pati...
21606878 - Human muscle proteome modifications following acute or repeated eccentric exercises.
6402538 - Exercise testing and training: clinical applications.
6488228 - Incidence and prognostic significance of symptomatic and asymptomatic exercise-induced ...
11404668 - Effect of resistance training on women's strength/power and occupational performances.
20620208 - Plasma nitrite flux predicts exercise performance in peripheral arterial disease after ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  AIM; IM    
Affiliation:
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / physiopathology*
Calcium Channel Blockers / pharmacology
Chromatography, High Pressure Liquid
Coronary Disease / diagnosis*
Exercise Test*
Fatty Acids, Nonesterified / blood*
Hemodynamics / drug effects
Humans
Nifedipine / analogs & derivatives,  pharmacology
Supination
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Fatty Acids, Nonesterified; 21829-25-4/Nifedipine; 75530-68-6/nilvadipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nuclear magnetic resonance imaging of acute myocardial infarction within 24 hours of chest pain onse...
Next Document:  Reemployment following implantation of the automatic cardioverter defibrillator.