| Early detection of myocardial dysfunction and heart failure. | |
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MedLine Citation:
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PMID: 20458341 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The impact of cardiac dysfunction and heart failure is continuing to escalate in the developed world. Treatment of this heterogeneous condition has focused on the symptomatic stage, often after irreversible remodeling and functional impairment have occurred. Early identification of cardiac dysfunction would allow implementation of early intervention strategies to delay the progression or to prevent the onset of heart failure altogether. Although screening methods for asymptomatic cardiac dysfunction have yet to be optimized, a staged approach for patients with predisposing risk factors using serological biomarkers followed by noninvasive imaging techniques may be useful. Existing biomarkers for cardiac dysfunction include B-type natriuretic peptide, troponins, and C-reactive protein. Novel markers such as protein ST2, galectin-3, and various prohormones are emerging and may provide prognostic information that is incremental to conventional clinical evaluation. Monitoring myocardial mechanics and molecular processes through three-dimensional speckle tracking and hybrid imaging modalities, such as PET-CT, may provide insight into disease manifestation before overt structural and physiological abnormalities. |
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Authors:
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Geoffrey de Couto; Maral Ouzounian; Peter P Liu |
Publication Detail:
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Type: Journal Article; Review Date: 2010-05-11 |
Journal Detail:
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Title: Nature reviews. Cardiology Volume: 7 ISSN: 1759-5010 ISO Abbreviation: Nat Rev Cardiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500075 Medline TA: Nat Rev Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 334-44 Citation Subset: IM |
Affiliation:
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Toronto General Hospital, University Health Network, NCSB 11-1266, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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