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Early detection of minor neurodevelopmental dysfunctions at age 6months in prematurely born neonates.
MedLine Citation:
PMID:  23084697     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate the 6-month neurodevelopmental outcomes of prematurely born neonates and find the determining neonatal factors of minor neurological dysfunctions (MNDs). STUDY DESIGN: We examined data collected prospectively on 151 infants born before 37th week of gestation in 2009-2010 who were assessed at 6months corrected age with the Bayley Scales of Infant Development-2nd Edition (BSID-II) and the Denver Developmental Screening Test (DDST). RESULTS: Of 151 neonates born before 37weeks, 20 (13.2%) had MNDs at 6months corrected age. These proportions were 21.6%, 13.2%, and 8.2% for neonates born before 28weeks, 29weeks to 32weeks, and 33weeks to 36weeks, respectively. Half of neonates with MNDs have a birth body weight of less than 1000g. BSID-II and DDST are highly correlated in assessing the MNDs of premature neonates at 6months corrected age. MND was independently associated with postnatal corticosteroid use (odds ratio [OR], 11.2; 95% confidence interval [CI], 1.9-66.0, P=0.008) and cholestasis (OR, 6.2; 95% CI, 1.16-33.1, P=0.033). CONCLUSIONS: Premature neonates, even those born at 33 to 36weeks, are found to have MNDs as early as 6months corrected age by BSID-II and DDST, with risk increasing as gestation decreases.
Jen-Fu Hsu; Ming-Horng Tsai; Shih-Ming Chu; Ren-Huei Fu; Ming-Chou Chiang; Fan-Ming Hwang; Miao-Ju Kuan; Yu-Shu Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Division of Pediatric Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
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