Document Detail

Early detection of left ventricular dysfunction with strain imaging in thalassemia patients.
MedLine Citation:
PMID:  20641107     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iron-mediated cardiomyopathy is the main cause of death in thalassemia patients. Early detection of cardiac abnormalities is important as aggressive chelation therapy may improve prognosis in these patients. The aim of this study is to evaluate left ventricular (LV) functions by tissue velocity imaging (TVI) and strain imaging (SI) in thalassemia patients without overt heart failure. METHODS: At total of 32 patients with beta-thalassemia major (mean age: 24.2+/-8.0 y, 22 male) and 25 healthy controls (mean age: 22.8+/-2.1 y, 20 male) were included. Conventional echocardiography, TVI, and SI were performed on all subjects. Tissue velocity imaging and SI measures included peak systolic, early and late diastolic myocardial velocities, peak systolic strain and strain rate, and early and late diastolic strain rate at the basal segments of the LV lateral and septal walls. RESULTS: There were no significant differences in LV ejection fraction and fractional shortening between the groups. However, systolic myocardial velocity of the lateral wall and systolic strain and strain rate of the septal and lateral walls were significantly lower in thalassemia patients. There was a significant negative correlation between LV mass index and systolic myocardial velocity of the lateral wall (r = - 0.29, P = .045) and septal systolic strain (r = - 0.45, P < .001). CONCLUSION: Thalassemia patients have regional systolic dysfunction in the LV lateral and septal walls, even if they do not have overt heart failure. Strain imaging is helpful in early detection of LV systolic dysfunction in thalassemia patients.
Ahmet Kaya Bilge; Engin Altinkaya; Beste Ozben; Figen Pekun; Kamil Adalet; Selim Yavuz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  33     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E29-34     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Wiley Periodicals, Inc.
Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Case-Control Studies
Disease Progression
Early Diagnosis
Echocardiography, Doppler, Color*
Myocardial Contraction
Predictive Value of Tests
Stroke Volume
Ventricular Dysfunction, Left / etiology,  physiopathology,  ultrasonography*
Ventricular Function, Left*
Young Adult
beta-Thalassemia / complications*,  physiopathology,  ultrasonography

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