Document Detail

Early detection of fetal cardiac abnormalities: how effective is it and how should we manage these patients?
MedLine Citation:
PMID:  25052917     Owner:  NLM     Status:  Publisher    
Congenital heart defects(CHDs), the most commonly occurring congenital malformations, cause significant mortality and morbidity. With the recognition of early markers for CHD and the development of better ultrasound resolution, interest has turned towards performing a screening anomaly scan, including the heart, together with the nuchal scan. It is also possible, with adequate skill and training, to competently perform an echocardiogram <16 weeks' gestation. This article reviews the detection of major CHD in the first- and early second-trimester including specific markers that help to identify high-risk groups for early fetal echocardiography(EFEC). CHD detection during first-trimester screening is low (2.3-56%) depending on the center's experience and the population studied. An increased nuchal translucency, abnormal ductus venosus flow and tricuspid regurgitation in the first-trimester are associated with an increased CHD risk and can be used together to identify high-risk fetuses for EFEC. EFEC requires skilled scanning and the expertise of a fetal echocardiographer. In high-risk populations it is 78.5% sensitive with a 74.5% concordance between the EFEC and the mid-gestational echocardiogram. The availability of qualified personnel and diagnostic accuracy are pre-requisites before EFEC can be introduced into management protocols. The limitations of EFEC should be recognized and a later confirmatory echocardiogram is recommended. This article is protected by copyright. All rights reserved.
Sally-Ann B Clur; Caterina M Bilardo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-22
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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