| Early detection of cell-free fetal DNA in maternal plasma. | |
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MedLine Citation:
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PMID: 17234369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We aimed to establish the earliest gestational age at which fetal DNA in maternal plasma could be detected and whether this was reliable at 12-13 weeks' gestation. STUDY DESIGN: A prospective observational cohort study of 32 pregnancies either after IVF or before prenatal diagnosis by CVS. Maternal blood was taken and RT-PCR was carried out to detect the multi-copy Y chromosome associated DSY14 gene. The end point was gender as assessed at delivery or on karyotype. RESULTS: Y signal was obtained as early as 14 days post conception (4 weeks' gestation) and has a good prediction rate by 12 weeks' gestation. CONCLUSION: Free fetal DNA allows very early prediction of fetal sex in some cases and could be useful for clinical use for X-linked conditions by the end of the first trimester. |
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Authors:
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S Illanes; M Denbow; C Kailasam; K Finning; P W Soothill |
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Publication Detail:
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Type: Journal Article Date: 2007-01-16 |
Journal Detail:
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Title: Early human development Volume: 83 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 563-6 Citation Subset: IM |
Affiliation:
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Fetal Medicine Research Unit, Division of Obstetrics and Gynaecology, University of Bristol, Bristol, UK. s.illanes@bristol.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Villi Sampling Chromosomes, Human, Y* DNA / blood* Female Gestational Age* Humans Male Predictive Value of Tests Pregnancy Pregnancy Trimester, First / blood Prospective Studies Reproducibility of Results Sex Determination (Analysis) / methods* Sperm Injections, Intracytoplasmic |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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