Document Detail

Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization.
MedLine Citation:
PMID:  20702916     Owner:  NLM     Status:  MEDLINE    
For detection of cardiac ischemia based on regional pCO(2) measurement, sensor drift becomes a problem when monitoring over several hours. A real-time drift correction algorithm was developed based on utilization of the time-derivative to distinguish between physiological responses and the drift, customized by measurements from a myocardial infarction porcine model (6 pigs, 23 sensors). IscAlert conductometric pCO(2) sensors were placed in the myocardial regions supplied by the left anterior descending coronary artery (LAD) and the left circumflex artery (LCX) while the LAD artery was fully occluded for 1, 3, 5 and 15 min leading to ischemia in the LAD-dependent region. The measured pCO(2), the drift-corrected pCO(2) (DeltapCO(2)) and its time-derivative (TDpCO(2)) were compared with respect to detection ability. Baseline stability in the DeltapCO(2) led to earlier, more accurate detection. The TDpCO(2) featured the earliest sensitivity, but with a lower specificity. Combining DeltapCO(2) and TDpCO(2) enables increased accuracy. Suggestions are given for the utilization of the parameters for an automated early warning and alarming system. In conclusion, early detection of cardiac ischemia is feasible using the conductometric pCO(2) sensor together with parameterization methods.
Christian Tronstad; Soeren E Pischke; Lars Holhjem; Tor Inge Tønnessen; Orjan G Martinsen; Sverre Grimnes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-11
Journal Detail:
Title:  Physiological measurement     Volume:  31     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-12     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  1241-55     Citation Subset:  IM    
Department of Clinical and Biomedical Engineering, Oslo University Hospital-Rikshospitalet, Norway.
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MeSH Terms
Carbon Dioxide / metabolism*
Conductometry / methods*
Early Diagnosis
Myocardial Ischemia / diagnosis*,  metabolism*
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide

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