| Early descriptions of acromegaly and gigantism and their historical evolution as clinical entities. | |
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MedLine Citation:
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PMID: 20887119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giants have been a subject of fascination throughout history. Whereas descriptions of giants have existed in the lay literature for millennia, the first attempt at a medical description was published by Johannes Wier in 1567. However, it was Pierre Marie, in 1886, who established the term "acromegaly" for the first time and established a distinct clinical diagnosis with clear clinical descriptions in 2 patients with the characteristic presentation. Multiple autopsy findings revealed a consistent correlation between acromegaly and pituitary enlargement. In 1909, Harvey Cushing postulated a “hormone of growth" as the underlying pathophysiological trigger involved in pituitary hypersecretion in patients with acromegaly. This theory was supported by his observations of clinical remission in patients with acromegaly in whom he had performed hypophysectomy. In this paper, the authors present some of the early accounts of acromegaly and gigantism, and describe its historical evolution as a medical and surgical entity. |
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Authors:
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Antonios Mammis; Jean Anderson Eloy; James K Liu |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Neurosurgical focus Volume: 29 ISSN: 1092-0684 ISO Abbreviation: Neurosurg Focus Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896471 Medline TA: Neurosurg Focus Country: United States |
Other Details:
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Languages: eng Pagination: E1 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, Division of Otolaryngology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Neurological Institute of New Jersey, Newark, New Jersey 07103, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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diagnosis*,
history* Adenoma / complications, diagnosis, history Adult Female France Gigantism / diagnosis*, history* History, 19th Century History, 20th Century Humans Male Middle Aged Neuroendocrinology / history Pituitary Neoplasms / complications, diagnosis, history* Terminology as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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