| Early and delayed onset cytomegalovirus infection of liver transplant recipients in endemic areas. | |
| | |
MedLine Citation:
|
PMID: 20430197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The delayed onset of cytomegalovirus (CMV) infection after liver transplantation can place patients at risk for graft failure and mortality. METHODS: We compared early versus delayed onset of CMV infection to identify risk factors for mortality among liver transplant recipients in an endemic area. RESULTS: Among 710 consecutive adult liver transplant recipients, incidence of CMV infection was 47.5% (337/710). Male gender, biliary complications, acute rejection episodes, antilymphocyte antibodies high hemoglobin, and high total bilirubin were significantly different among patients with delayed versus early onset CMV infections. The overall incidence of early versus delayed CMV infections was 43.1% (306/710) versus 4.4% (31/710). Among them, 11.1% (34/306) and 25.8% (8/31) of patients developed CMV disease. CONCLUSION: These results showed that a higher proportion of patients developed disease among delayed CMV infected patients (P=.039). The overall and graft survival curves for patients with early onset CMV infections were better than those of patients who had delayed onset CMV infections (P=.026 and P=.014). Recurrence of hepatitis B virus, hepatic dysfunction, and retransplantation were associated with increased mortality among patients who had a delayed CMV infection. |
| | |
Authors:
|
J M Kim; S J Kim; J-W Joh; C H D Kwon; M Shin; E Y Kim; J I Moon; G O Jung; G S Choi; S K Lee |
Related Documents
:
|
6270027 - The effect of infection on t lymphocyte subpopulations: a preliminary report. 19811947 - Does hygiene counseling have an impact on the rate of cmv primary infection during preg... 1322557 - Foscarnet for treatment of cytomegalovirus infections in bone marrow transplant recipie... 9099507 - Cytomegalovirus infection in the pregnant mother, fetus, and newborn infant. 6679147 - Quantitative studies on the role of ureaplasma urealyticum in non-gonococcal urethritis... 3145857 - Mouse model for evaluation of antibiotic treatment of acute and chronic infections. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-30 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 884-9 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antiviral Agents / therapeutic use Cytomegalovirus Infections / epidemiology*, mortality, prevention & control Endemic Diseases / statistics & numerical data Female Follow-Up Studies Graft Survival Hepatitis B / surgery Hepatitis C / surgery Humans Liver Transplantation / adverse effects*, mortality Male Middle Aged Patient Selection Reoperation / statistics & numerical data Retrospective Studies Sex Characteristics Survival Analysis Survival Rate Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does hepatic graft weight affect the reduction of spleen size after living donor liver transplantati...
Next Document: The Risk Factors for Cytomegalovirus Syndrome and Tissue-invasive Cytomegalovirus Disease in Liver T...