Document Detail

Early decrease in density of mononuclear leukocyte beta-adrenoceptors in depressed patients following amineptine treatment: possible relation to clinical efficiency.
MedLine Citation:
PMID:  1650488     Owner:  NLM     Status:  MEDLINE    
1. The effect of chronic amineptine treatment (200mg/day) on beta-adrenoceptor density of intact mononuclear leukocytes (MNL) was examined in unmedicated major unipolar depressed patients. 2. Pretreatment parameters of (-)-[125I]-iodopindolol specific binding did not differ significantly from age- and sex-matched healthy controls as the patients were only moderately depressed. 3. All patients showed a highly significant clinical improvement as assessed by the AMDP-depression scale after one week of amineptine (D7), while 2 patients relapsed after one month of treatment (D28) and were considered to be non-responders. 4. The maximal density of beta-adrenoceptors (Bmax) was significantly decreased at D7 (by 33%) compared to pretreatment level (D0) in the treatment responders and remained lower at D28, although the difference was no longer significant. No alteration in beta-receptor affinity (Kd) was detected during the treatment. 5. These results indicate that treatment with amineptine, an antidepressant drug known to selectively inhibit the dopamine uptake system, can rapidly affect MNL beta-adrenoceptors. 6. Moreover, the present findings show that the reduction in MNL beta-adrenoceptor density, which is associated with a stable clinical improvement, may provide a predictive index for successful antidepressant treatment.
P Mazzola; R Jeanningros; J M Azorin; L Aligne; R Tissot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-67     Citation Subset:  IM    
Unité de Psychiatrie Biologique, C.N.R.S., Marseille, France.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Depressive Disorder / metabolism*
Dibenzocycloheptenes / therapeutic use*
Iodine Radioisotopes / diagnostic use
Middle Aged
Neutrophils / drug effects,  metabolism*
Pindolol / analogs & derivatives,  metabolism
Psychiatric Status Rating Scales
Receptors, Adrenergic, beta / drug effects,  metabolism*
Reg. No./Substance:
0/Antidepressive Agents; 0/Dibenzocycloheptenes; 0/Iodine Radioisotopes; 0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 57574-09-1/amineptin; 76875-01-9/3-iodopindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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