Document Detail

Early corneal findings in Cogan's syndrome.
MedLine Citation:
PMID:  6493698     Owner:  NLM     Status:  MEDLINE    
We evaluated the ocular manifestations of Cogan's syndrome in 13 consecutive patients. The most frequent and earliest ocular finding was bilateral peripheral subepithelial keratitis consisting of faint, nummular lesions. The subepithelial keratitis was responsive to topical administration of corticosteroids. Peripheral subepithelial keratitis was seen in four patients and strongly suspected on review of history in three additional patients. Deep stromal keratitis was seen in two patients, while only one patient developed classic findings of Cogan's syndrome, ie. interstitial keratitis with vascularization. Additionally, five patients presented with noncorneal ocular inflammatory disease and deafness (atypical Cogan's syndrome). Early subepithelial keratitis in Cogan's syndrome may be mistakenly diagnosed as trival ocular inflammatory disease, and suppressed by topical corticosteroids, resulting in delayed diagnosis of Cogan's syndrome in the absence of classic corneal findings. Early diagnosis of Cogan's syndrome is important inasmuch as prompt treatment of cochlear symptoms with systemic corticosteroids may prevent or ameliorate deafness.
L M Cobo; B F Haynes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  91     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-28     Completed Date:  1984-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-7     Citation Subset:  IM    
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MeSH Terms
Cornea / pathology
Deafness / complications,  diagnosis
Keratitis / complications,  etiology*,  pathology
Middle Aged
Vertigo / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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