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Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo oxygenase inhibitor naïve population.
MedLine Citation:
PMID:  23181767     Owner:  NLM     Status:  Publisher    
AIMS: To examine the relationship between early duct diameter and patent ductus arteriosus (PDA) symptoms. METHODS: A retrospective study of infants < 29 weeks gestation with early colour Doppler assessment of PDA diameter in whom PDA was managed conservatively, without cyclo-oxygenase inhibitor treatment. RESULTS: Gestation and birth weight, [median (range)], were 26 (23-28) weeks and 865 (500-1440) g respectively. Symptomatic PDA developed in 20 (68.9%) infants, with 11 (37.9%) referred for PDA ligation at 24 (17-30) days. Symptoms resolved spontaneously in 7 (24.1%) at 19 (7-32) days. There were 6 (20.7%) deaths, including four early neonatal deaths with large PDA. Early colour Doppler PDA diameter >1.5mm (n=20) predicted development of symptomatic PDA (sensitivity 91%, specificity 100%), but symptoms resolved spontaneously without treatment in 30%. There was a significant linear correlation (p< 0.001) with increasing early PDA diameter and the development of more persistent PDA symptoms, early neonatal mortality and morbidity. CONCLUSIONS: In our COI naïve population, the mortality and morbidity associated with prolonged exposure to unrestricted ducts is high. Not all infants with early PDA diameter >1.5mm have persistent symptomatic PDA but early PDA diameter could be utilised to identify those infants at greatest risk of adverse outcome associated with PDA. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.
Anne Marie Heuchan; David Young
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-26
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.
Department of Neonatal Medicine, The Royal Hospital for Sick Children, Yorkhill, Glasgow, G3 8SJ, Scotland, UK.
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