| Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo oxygenase inhibitor naïve population. | |
| | |
MedLine Citation:
|
PMID: 23181767 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: To examine the relationship between early duct diameter and patent ductus arteriosus (PDA) symptoms. METHODS: A retrospective study of infants < 29 weeks gestation with early colour Doppler assessment of PDA diameter in whom PDA was managed conservatively, without cyclo-oxygenase inhibitor treatment. RESULTS: Gestation and birth weight, [median (range)], were 26 (23-28) weeks and 865 (500-1440) g respectively. Symptomatic PDA developed in 20 (68.9%) infants, with 11 (37.9%) referred for PDA ligation at 24 (17-30) days. Symptoms resolved spontaneously in 7 (24.1%) at 19 (7-32) days. There were 6 (20.7%) deaths, including four early neonatal deaths with large PDA. Early colour Doppler PDA diameter >1.5mm (n=20) predicted development of symptomatic PDA (sensitivity 91%, specificity 100%), but symptoms resolved spontaneously without treatment in 30%. There was a significant linear correlation (p< 0.001) with increasing early PDA diameter and the development of more persistent PDA symptoms, early neonatal mortality and morbidity. CONCLUSIONS: In our COI naïve population, the mortality and morbidity associated with prolonged exposure to unrestricted ducts is high. Not all infants with early PDA diameter >1.5mm have persistent symptomatic PDA but early PDA diameter could be utilised to identify those infants at greatest risk of adverse outcome associated with PDA. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica. |
| | |
Authors:
|
Anne Marie Heuchan; David Young |
Related Documents
:
|
1832257 - Early predictor of the efficacy of immunoprophylaxis against perinatal hepatitis b tran... 1113797 - Vertical transmission of hepatitis b antigen in taiwan. 22129547 - Near-infrared spectroscopy as a hemodynamic monitor in critical illness. 10808607 - Preventing mother-to-child transmission of hiv: practical strategies for developing cou... 8001917 - Health of populations in northern queensland aboriginal communities: change and continu... 14615727 - Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-26 |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica. |
Affiliation:
|
Department of Neonatal Medicine, The Royal Hospital for Sick Children, Yorkhill, Glasgow, G3 8SJ, Scotland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intersubband absorption properties of high Al content AlxGa1-xN/GaN multiple quantum wells grown wit...
Next Document: Efficient Synthesis of Chiral 2,2'-Bipyrrolidines by an anti-Selective Alkene Diamination.