Document Detail

Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
MedLine Citation:
PMID:  106289     Owner:  NLM     Status:  MEDLINE    
Opiate maintenance with methadone has been demonstrated to be an effective treatment modality for many chronic heroin-dependent individuals. However, the many clinical and societal advantages of a longer-lasting medication prompted the development of LAAM, which could be administered three days a week rather than daily. Early Phase II clinical trials of LAAM in about 750 patients have been reviewed and have demonstrated the safety and effectiveness of this drug and confirmed its usefulness for treatment of this chronic disease.
J D Blaine
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  NIDA research monograph     Volume:  -     ISSN:  1046-9516     ISO Abbreviation:  NIDA Res. Monogr.     Publication Date:  1978  
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811762     Medline TA:  NIDA Res Monogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-59     Citation Subset:  IM    
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MeSH Terms
Arousal / drug effects
Clinical Trials as Topic
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Tolerance
Emotions / drug effects
Heroin Dependence / rehabilitation*
Methadone / analogs & derivatives*,  therapeutic use
Methadyl Acetate / administration & dosage,  metabolism,  therapeutic use*
Pain, Intractable / drug therapy
Substance Withdrawal Syndrome / drug therapy
Reg. No./Substance:
509-74-0/Methadyl Acetate; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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