| Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence. | |
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MedLine Citation:
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PMID: 106289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opiate maintenance with methadone has been demonstrated to be an effective treatment modality for many chronic heroin-dependent individuals. However, the many clinical and societal advantages of a longer-lasting medication prompted the development of LAAM, which could be administered three days a week rather than daily. Early Phase II clinical trials of LAAM in about 750 patients have been reviewed and have demonstrated the safety and effectiveness of this drug and confirmed its usefulness for treatment of this chronic disease. |
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Authors:
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J D Blaine |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: NIDA research monograph Volume: - ISSN: 1046-9516 ISO Abbreviation: NIDA Res. Monogr. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811762 Medline TA: NIDA Res Monogr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 249-59 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arousal
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drug effects Clinical Trials as Topic Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug Tolerance Emotions / drug effects Heroin Dependence / rehabilitation* Humans Methadone / analogs & derivatives*, therapeutic use Methadyl Acetate / administration & dosage, metabolism, therapeutic use* Pain, Intractable / drug therapy Substance Withdrawal Syndrome / drug therapy |
| Chemical | |
Reg. No./Substance:
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509-74-0/Methadyl Acetate; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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