Document Detail


Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
MedLine Citation:
PMID:  106289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Opiate maintenance with methadone has been demonstrated to be an effective treatment modality for many chronic heroin-dependent individuals. However, the many clinical and societal advantages of a longer-lasting medication prompted the development of LAAM, which could be administered three days a week rather than daily. Early Phase II clinical trials of LAAM in about 750 patients have been reviewed and have demonstrated the safety and effectiveness of this drug and confirmed its usefulness for treatment of this chronic disease.
Authors:
J D Blaine
Related Documents :
23925919 - Multicenter experience of the newly designed covered metallic ureteral stent for malign...
24735099 - Modified penile disassembly technique for boys with epispadias and those undergoing com...
19653509 - Mortality of nontarget arthropods from an aerial application of pyrethrins.
18635689 - Incidence of craving for and abuse of gamma-hydroxybutyric acid (ghb) in different popu...
12968119 - The experience of manual lymph drainage as an aspect of treatment for lymphoedema.
24251239 - Carotid and vagal body paragangliomas.
18443889 - A novel weight-reducing operation: lateral subtotal gastrectomy with silastic ring plus...
6824869 - Sclerosant therapy for hydroceles and epididymal cysts.
8496519 - Serial angiographic follow-up after palmaz-schatz stent implantation: comparison with c...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  NIDA research monograph     Volume:  -     ISSN:  1046-9516     ISO Abbreviation:  NIDA Res. Monogr.     Publication Date:  1978  
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811762     Medline TA:  NIDA Res Monogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-59     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Arousal / drug effects
Clinical Trials as Topic
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Tolerance
Emotions / drug effects
Heroin Dependence / rehabilitation*
Humans
Methadone / analogs & derivatives*,  therapeutic use
Methadyl Acetate / administration & dosage,  metabolism,  therapeutic use*
Pain, Intractable / drug therapy
Substance Withdrawal Syndrome / drug therapy
Chemical
Reg. No./Substance:
509-74-0/Methadyl Acetate; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multimodality treatment of narcotic addiction: an overview.
Next Document:  (+)-Cyanidanol-3 as inhibitor of prostaglandin synthetase. Studies on renal medulla and liver of the...