Document Detail

Early clinical experience with the new Amplatzer Ductal Occluder II for closure of the persistent arterial duct.
MedLine Citation:
PMID:  19360878     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the early single-center clinical experience with the Amplatzer Ductal Occluder II (ADO II). METHODS: All patients undergoing attempted transcatheter closure of persistent arterial duct (PDA) with the ADO II were included. Data collected included demographic, clinical, and echocardiographic parameters. RESULTS: From March until September 2008, 29 procedures were undertaken in 27 patients (21 female). Median age was 1.4 years (range 0.4-76 years) with median weight 9.4 kg (range 4.7-108 kg). A transarterial approach was used in 2 patients. The median minimum ductal diameter was 2.7 mm (range 1.7-5). ADO II was released in 25 patients (92.5%). Two patients had significant residual shunting following deployment of ADO II and underwent closure with Amplatzer ductal occluder (ADO I). Postprocedural echocardiography identified one occluder had changed position with development of a significant leak and one occluder had embolized to the left pulmonary artery. Both occluders were retrieved successfully at a second catheter procedure. Complete occlusion was noted predischarge in 22 of the remaining 23 occluders (96%). One patient had mild flow acceleration in the left pulmonary artery which has resolved. CONCLUSIONS: The ADO II is highly effective at providing rapid occlusion of morphologically varied PDAs. Occluder design allows closure with arterial or venous approach and delivery with 4 or 5 F delivery catheters. Stable occluder position is dependent on correct positioning of both aortic and pulmonary discs. A larger range of sizes and configurations of this occluder may be required to successfully occlude all ductal sizes and morphologies.
Jonathan Forsey; Damien Kenny; Gareth Morgan; Alison Hayes; Mark Turner; Andrew Tometzki; Robin Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-23     Citation Subset:  IM    
Bristol Congenital Heart Centre, University Hospitals Bristol, NHS Foundation Trust, Bristol, UK.
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MeSH Terms
Balloon Occlusion / adverse effects,  instrumentation*
Child, Preschool
Ductus Arteriosus, Patent / physiopathology,  radiography,  therapy*,  ultrasonography
Heart Catheterization / adverse effects,  instrumentation*
Patient Selection
Prosthesis Design
Retrospective Studies
Septal Occluder Device*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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