Document Detail

Early clinical evaluation of the intravenous treatment of acute myocardial infarction with anisoylated plasminogen streptokinase activator complex.
MedLine Citation:
PMID:  3315575     Owner:  NLM     Status:  MEDLINE    
50 consecutive patients with acute myocardial infarction and symptoms of less than 4 hours duration were treated with anisoylated plasminogen streptokinase activator complex (APSAC) 30U intravenously as a bolus injection over 5 minutes. An open infarct-related artery was found in 32 patients (64%) when the first coronary angiography was taken 66 +/- 21 minutes after APSAC. Complete reperfusion was subsequently seen in 10 of 18 patients with an occluded infarct-related artery 74 +/- 16 minutes after injection of APSAC. Thus, a patient infarct-related artery was seen in 42 patients (84%) within 68 +/- 20 minutes. A control coronary angiography was performed in 37 patients (74%) after 25 +/- 19 days. Reocclusion was found in 5 patients. The minimal cross-sectional area of the residual coronary stenosis increased from 1.3 +/- 0.9 mm2 to 1.8 +/- 1.9 mm2. Patients with residual thrombi after coronary thrombolysis (n = 13) demonstrated an increase of the minimal cross-sectional area of the residual stenosis from 1.2 +/- 0.8 to 2.6 +/- 2.3 mm2, whereas those without residual thrombi showed only minor changes of the minimal cross-sectional area (1.3 +/- 0.9 to 1.2 +/- 1.2 mm2). Thus, APSAC demonstrated a high patency rate and a low reocclusion rate after intravenous administration. The prolonged fibrinolytic activity of APSAC leads to a further regression of the residual coronary stenosis among patients with coronary thrombi after reperfusion.
W Kasper; T Meinertz; H Wollschläger; T Bonzel; C Chen; T Hofmann; A Zeiher; H Drexler; H Just
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Drugs     Volume:  33 Suppl 3     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-07     Completed Date:  1988-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  112-6     Citation Subset:  IM    
Klinikum der Albert-Ludwigs-Universität, Med. Universitäts Klinik, Abteilung Innere Medizin III, Kardiologie, Freiburg.
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MeSH Terms
Clinical Trials as Topic
Coronary Angiography
Coronary Circulation / drug effects
Fibrinogen / metabolism
Fibrinolytic Agents / adverse effects,  therapeutic use*
Follow-Up Studies
Hemorrhage / chemically induced
Injections, Intravenous
Middle Aged
Myocardial Infarction / drug therapy*
Plasminogen / adverse effects,  therapeutic use*
Streptokinase / adverse effects,  therapeutic use*
Vascular Patency / drug effects
Reg. No./Substance:
0/Fibrinolytic Agents; 81669-57-0/Anistreplase; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

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