| Early cholestasis in premature infants receiving total parenteral nutrition: a possible consequence of shock and hypoxia. | |
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MedLine Citation:
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PMID: 8555124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report 18 premature infants (gestational age: 31.1 weeks +/- 2.6 [mean +/- SD] (range: 28-36]) with necrotizing enterocolitis (NEC) who developed total parenteral nutrition (TPN) associated cholestasis. Liver function tests were performed at the start of TPN (D1) and repeated once a week. Considering the date of cholestasis onset (direct bilirubin > 30 mumol/l and/or serum bile salts > 10 mumol/l), the patients can be divided in two groups. The first group consisted of 9 patients who had cholestasis at D1. In these patients shock and/or hypoxia occurred prior to D1 and were the only risk factors of cholestasis identified before D1. The second group consisted of 9 patients who developed cholestasis after D1 and in whom the cause of cholestasis was multifactorial (sepsis, lack of enteral feeding, shock and/or hypoxia). These results suggest that shock and/or hypoxia can be responsible for early cholestasis in premature infants. We conclude that shock and hypoxia should be considered when discussing TPN-associated cholestasis. |
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Authors:
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E Jacquemin; C Maurage; J C Borderon; F Gold; J Laugier; J C Rolland |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie Volume: 5 ISSN: 0939-7248 ISO Abbreviation: Eur J Pediatr Surg Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-02-27 Completed Date: 1996-02-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105263 Medline TA: Eur J Pediatr Surg Country: GERMANY |
Other Details:
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Languages: eng Pagination: 259-61 Citation Subset: IM |
Affiliation:
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Gastroenterology Unit, Clocheville Children's Hospital, Tours, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications* Cholestasis / diagnosis, etiology* Female Humans Infant, Newborn Infant, Premature, Diseases / etiology* Liver Function Tests Male Parenteral Nutrition, Total / adverse effects* Prospective Studies Risk Factors Shock / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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