Document Detail

Early cholestasis in premature infants receiving total parenteral nutrition: a possible consequence of shock and hypoxia.
MedLine Citation:
PMID:  8555124     Owner:  NLM     Status:  MEDLINE    
We report 18 premature infants (gestational age: 31.1 weeks +/- 2.6 [mean +/- SD] (range: 28-36]) with necrotizing enterocolitis (NEC) who developed total parenteral nutrition (TPN) associated cholestasis. Liver function tests were performed at the start of TPN (D1) and repeated once a week. Considering the date of cholestasis onset (direct bilirubin > 30 mumol/l and/or serum bile salts > 10 mumol/l), the patients can be divided in two groups. The first group consisted of 9 patients who had cholestasis at D1. In these patients shock and/or hypoxia occurred prior to D1 and were the only risk factors of cholestasis identified before D1. The second group consisted of 9 patients who developed cholestasis after D1 and in whom the cause of cholestasis was multifactorial (sepsis, lack of enteral feeding, shock and/or hypoxia). These results suggest that shock and/or hypoxia can be responsible for early cholestasis in premature infants. We conclude that shock and hypoxia should be considered when discussing TPN-associated cholestasis.
E Jacquemin; C Maurage; J C Borderon; F Gold; J Laugier; J C Rolland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  5     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  259-61     Citation Subset:  IM    
Gastroenterology Unit, Clocheville Children's Hospital, Tours, France.
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MeSH Terms
Anoxia / complications*
Cholestasis / diagnosis,  etiology*
Infant, Newborn
Infant, Premature, Diseases / etiology*
Liver Function Tests
Parenteral Nutrition, Total / adverse effects*
Prospective Studies
Risk Factors
Shock / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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