Document Detail

Early childhood general anaesthesia exposure and neurocognitive development.
MedLine Citation:
PMID:  21148656     Owner:  NLM     Status:  MEDLINE    
A great deal of concern has recently arisen regarding the safety of anaesthesia in infants and children. There is mounting and convincing preclinical evidence in rodents and non-human primates that anaesthetics in common clinical use are neurotoxic to the developing brain in vitro and cause long-term neurobehavioural abnormalities in vivo. An estimated 6 million children (including 1.5 million infants) undergo surgery and anaesthesia each year in the USA alone, so the clinical relevance of anaesthetic neurotoxicity is an urgent matter of public health. Clinical studies that have been conducted on the long-term neurodevelopmental effects of anaesthetic agents in infants and children are retrospective analyses of existing data. Two large-scale clinical studies are currently underway to further address this issue. The PANDA study is a large-scale, multisite, ambi-directional sibling-matched cohort study in the USA. The aim of this study is to examine the neurodevelopmental effects of exposure to general anaesthesia during inguinal hernia surgery before 36 months of age. Another large-scale study is the GAS study, which will compare the neurodevelopmental outcome between two anaesthetic techniques, general sevoflurane anaesthesia and regional anaesthesia, in infants undergoing inguinal hernia repair. These study results should contribute significant information related to anaesthetic neurotoxicity in children.
L Sun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  105 Suppl 1     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  i61-8     Citation Subset:  IM    
Department of Anesthesiology and Pediatrics, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Anesthesia, General / adverse effects*
Anesthetics, General / adverse effects
Brain / drug effects,  growth & development
Child, Preschool
Cognition Disorders / chemically induced*
Developmental Disabilities / chemically induced*
Disease Models, Animal
Evidence-Based Medicine / methods
Grant Support
Reg. No./Substance:
0/Anesthetics, General

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